CAS Number109244-58-8
SynonymsMFCD00285712; Benzoic acid, 2-(3,6-diamino-9H-xanthen-9-yl)-, methyl ester; Methyl 2-(3,6-diamino-9H-xanthen-9-yl)benzoate
Molecular FormulaC21H18N2O3
Molecular Weight346.38
Purity≥95%
Density1.3±0.1 g/cm3
Boiling Point526.9±50.0 °C at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 109244-58-8 |
| Catalog No. | 2A-9050449 |
| Chinese Name | 二氢若丹明123 |
| Synonyms | MFCD00285712; Benzoic acid, 2-(3,6-diamino-9H-xanthen-9-yl)-, methyl ester; Methyl 2-(3,6-diamino-9H-xanthen-9-yl)benzoate |
| Molecular Formula | C21H18N2O3 |
| Molecular Weight | 346.38 |
| Purity | ≥95 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 526.9±50.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | Store airtight in a cool, dry warehouse. Refrigera |
| Application | Dihydrorhodamine 123 is a fluorescent probe (λex=488 nm, λem=525 nm). |
| HTC | 2932999099 |
| PubChem ID | 24893337 |
| MDL Number | MFCD00285712 |
| SMILES | COC(=O)c1ccccc1C2c3ccc(N)cc3Oc4cc(N)ccc24 |
| InChI | 1S/C21H18N2O3/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20/h2-11,20H,22-23H2,1H3 |
| InChI Key | FNEZBBILNYNQGC-UHFFFAOYSA-N |
| Beilstein/REAXYS | 5989965 |
| NACRES Code | NA.47 |
| UNSPSC | 12171500 |
| Hazard Symbols | transportation |
| MSDS | msds/50449_1_109244_58_8.pdf |
| Bioactivity | Dihydrorhodamine 123 is a fluorescent probe (λex=488 nm, λem=525 nm). Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Dye Reagents In Vitro In the presence of 10 μM Dihydrorhodamine 123 (DHR) the stimulation of the neutrophil NADPH oxidase by the addition of 50 nM phorbol 12-myristate 13-acetat (PMA) resultes in an increase in the rate of rhodamine generation. The fluorescent intensity of the cells, in the presence of 10 μM Dihydrorhodamine 123, increases with time following the addition of 50 nM PMA. In the presence of 10 μM Dihydrorhodamine 123, induced HL60 cells show a sustained increase in fluorescence following the addition of 50 nM PMA[1]. Cell Assay The HL60 cells are incubated at 6×106 cells/mL in Krebs-Ringer buffer at 37°C containing 10 μM Dihydrorhodamine 123 (DHR). The generation of O2- is initiated by the addition of 50 nM phorbol 12-myristate 13-acetat (PMA) and the progress of the generation of rhodamine 123 is monitored in 50-μL aliquots (3×105 cells) diluted tenfold before analysis. The uninduced HL60 cells are loaded with 5 μM carboxy SNARF-1 AM acetate (SNARF-AM) in the Na+ medium for 10 min at 37°C and washed by centrifugation and resuspension to remove unhydrolysed SNARF ester[1]. References [1]. Lydia M. Henderson et al. Dihydrorhodamine 123: a fluorescent probe for superoxide generation? Eur.J.Biochem. 217, 973-980. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 526.9±50.0 °C at 760 mmHg Molecular Formula C21H18N2O3 Molecular Weight 346.379 Flash Point 222.4±26.4 °C Exact Mass 346.131744 PSA 87.57000 LogP 1.84 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.684 InChIKey FNEZBBILNYNQGC-UHFFFAOYSA-N SMILES COC(=O)c1ccccc1C1c2ccc(N)cc2Oc2cc(N)ccc21 Storage condition -20°C |
| Use of | Dihydrorhodamine 123 is a fluorescent probe (λex=488 nm, λem=525 nm). Properties Articles88 Name Dihydrorhodamine 123 Synonym More Synonyms Dihydrorhodamine 123 Biological Activity Description Dihydrorhodamine 123 is a fluorescent probe (λex=488 nm, λem=525 nm). Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Dye Reagents References [1]. Lydia M. Henderson et al. Dihydrorhodamine 123: a fluorescent probe for superoxide generation? Eur.J.Biochem. 217, 973-980. Chemical & Physical Properties Molecular Formula C21H18N2O3 Exact Mass 346.131744 PSA 87.57000 Index of Refraction 1.684 InChIKey FNEZBBILNYNQGC-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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