| Chemical & Physical Properties | |
|---|---|
| CAS Number | 105219-56-5 |
| Catalog No. | 2A-9050174 |
| Chinese Name | 阿帕泛 |
| Synonyms | Apafant |
| Molecular Formula | C22H22ClN5O2S |
| Molecular Weight | 455.96 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 720.2±70.0 °C at 760 mmHg |
| Melting Point | 186-188ºC |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist that inhibits PAF binding to the human PAF receptor with a Ki of 9.9 nM. |
| PubChem ID | 329825250 |
| MDL Number | MFCD00865271 |
| SMILES | Cc1nnc2CN=C(c3ccccc3Cl)c4cc(CCC(=O)N5CCOCC5)sc4-n12 |
| InChI | 1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3 |
| InChI Key | JGPJQFOROWSRRS-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/50174_1_105219_56_5.pdf |
| Bioactivity | Apafant (WEB 2086), a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Target Ki: 9.9 nM (Platelet-activating factor)[1] References [1]. Kato M, et al. Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. J Pharmacol Sci. 2004 Aug;95(4):435-42. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 720.2±70.0 °C at 760 mmHg Melting Point 186-188ºC Molecular Formula C22H22ClN5O2S Molecular Weight 455.96 Flash Point 389.4±35.7 °C Exact Mass 455.118286 PSA 100.85000 LogP 1.32 Vapour Pressure 0.0±2.3 mmHg at 25°C Index of Refraction 1.734 InChIKey JGPJQFOROWSRRS-UHFFFAOYSA-N SMILES Cc1nnc2n1-c1sc(CCC(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2 Storage condition 2-8°C |
| Use of | Apafant (WEB 2086), a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM[1]. Properties Articles32 Name Apafant Synonym More Synonyms Apafant Biological Activity Description Apafant (WEB 2086), a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Ki: 9.9 nM (Platelet-activating factor)[1] References [1]. Kato M, et al. Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. J Pharmacol Sci. 2004 Aug;95(4):435-42. Chemical & Physical Properties Exact Mass 455.118286 PSA 100.85000 Index of Refraction 1.734 InChIKey JGPJQFOROWSRRS-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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