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Splenopentin diacetate structure, CAS 105184-37-0

Splenopentin diacetate

CAS Number105184-37-0

SynonymsSP-5 ACETATE SALT; SPLENOPENTIN ACETATE SALT; ARG-LYS-GLU-VAL-TYR ACETATE; Splenopentin diacetate; SPLENIN FRAGMENT 32-36 ACETATE SALT; SP-5,Splenin Fragment 32-36,Splenopentin; ARG-LYS-GLU-VAL-TYR ACETATE SALT

Molecular FormulaC33H55N9O11

Molecular Weight753.84300

Purity98.00%

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Cat. No.: 2A-9050170 Purity: 98.00%
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Quality Control of [ 105184-37-0 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number105184-37-0
Catalog No.2A-9050170
Chinese Name醋酸脾脏五肽
SynonymsSP-5 ACETATE SALT; SPLENOPENTIN ACETATE SALT; ARG-LYS-GLU-VAL-TYR ACETATE; Splenopentin diacetate; SPLENIN FRAGMENT 32-36 ACETATE SALT; SP-5,Splenin Fragment 32-36,Splenopentin; ARG-LYS-GLU-VAL-TYR ACETATE SALT
Molecular FormulaC33H55N9O11
Molecular Weight753.84300
Purity98.00
Storage Condition−20°C
ApplicationSplenopentin diacetate is a synthetic immunomodulatory pentapeptide corresponding to residues 32-36 of the splenic hormone splenin. Splenopentin diacetate affects early T-cell and B-cell differentiati
SMILESCC(=O)O.CC(C)C(NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(N)CCCN=C(N)N)C(=O)NC(Cc1ccc(O)cc1)C(=O)O
InChI KeyLVTBFNOBCJAFQW-UHFFFAOYSA-N
BioactivitySplenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology In Vitro Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity[2]. Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells[3]. In Vivo Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice[4]. Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice[3]. Animal Model: Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days[4] Dosage: 1 mg/kg Administration: I.p. three times a week for 7-90 days Result: Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment. Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops. References [1]. Singh VK, et, al. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68. [2]. Rastogi A, et, al. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5. [3]. Audhya T, et, al. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc Natl Acad Sci U S A. 1984 May;81(9):2847-9. [4]. Gruner S, et, al. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9. Chemical & Physical Properties Molecular Formula C33H55N9O11 Molecular Weight 753.84300 Exact Mass 753.40200 PSA 362.47000 LogP 2.44490 InChIKey LVTBFNOBCJAFQW-UHFFFAOYSA-N SMILES CC(=O)O.CC(C)C(NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(N)CCCN=C(N)N)C(=O)NC(Cc1ccc(O)cc1)C(=O)O Storage condition −20°C
Use ofSplenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation[1][2]. Properties Name Splenopentin Acetate Synonym More Synonyms Splenopentin diacetate Biological Activity Description Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology In Vitro Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity[2]. Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells[3]. References [1]. Singh VK, et, al. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68. [2]. Rastogi A, et, al. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5. [3]. Audhya T, et, al. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc Natl Acad Sci U S A. 1984 May;81(9):2847-9. [4]. Gruner S, et, al. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9. Chemical & Physical Properties Molecular Formula C33H55N9O11 Exact Mass 753.40200 PSA 362.47000 LogP 2.44490 InChIKey LVTBFNOBCJAFQW-UHFFFAOYSA-N
Transport InfoProduct Name: Splenopentin Acetate
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