CAS Number104987-12-4
Synonymsimmunomycin; (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol,iMMucillin H; Ascomycin; (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol; Isopamphos; Immucillin-H; 1,4-dideoxy-(1S)-1-C-(4-hydroxypyrrolo[3,2-d]pyrimidin-7-yl)-1,4-imino-D-ribitol; MFCD00467131; Fodosine
Molecular FormulaC43H69NO12
Molecular Weight792.01
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point868.3±75.0 °C at 760 mmHg
Melting Point153-157ºC
Appearanceliquid
EINECS200-835-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 104987-12-4 |
| Catalog No. | 2A-9050155 |
| Chinese Name | 长川霉素 |
| Synonyms | immunomycin; (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol,iMMucillin H; Ascomycin; (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol; Isopamphos; Immucillin-H; 1,4-dideoxy-(1S)-1-C-(4-hydroxypyrrolo[3,2-d]pyrimidin-7-yl)-1,4-imino-D-ribitol; MFCD00467131; Fodosine |
| Molecular Formula | C43H69NO12 |
| Molecular Weight | 792.01 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 868.3±75.0 °C at 760 mmHg |
| Melting Point | 153-157ºC |
| Appearance | liquid |
| Water Solubility | Soluble in DMSO at 65mg/ml; soluble in ethanol at |
| Storage Condition | −20°C |
| Application | Ascomycin (Immunomycin, FR-900520, FK520) is an analog of tacrolimus (FK506) and a strong immunosuppressant. |
| EINECS | 200-835-2 |
| HTC | 29419090 |
| SMILES | CCC1\C=C(C)\CC(C)CC(OC)C2OC(O)(C(C)CC2OC)C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)C(O)CC1=O)\C(C)=C\C4CCC(O)C(C4)OC |
| InChI | 1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+ |
| InChI Key | ZDQSOHOQTUFQEM-AMASXYNMSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/50155_1_104987_12_4.pdf |
| Bioactivity | Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. IC50 Value: 0.55 nM [1]Target: in vitro: When we used either CD4+CD8+ thymocytes or peripheral T cells activated by phorbol ester and ionomycin, the cell surface induction of CD5 was also partially blocked by CsA, FK-520 and rapamycin [2]. Ascomycinalso had a 3-fold lower immunosuppressive potency in a popliteal lymph node hyperplasia assay, resulting in an equivalent therapeutic index consistent with a common mechanistic dependence on calcineurin inhibition [3].in vivo: In 14-day studies, nephrotoxicity was not induced by continuous i.p. infusion of ascomycin at 10 mg/kg/day or daily oral administration (up to 50 mg/kg/day) in rats on a normal diet, nor by continuous i.v. infusion (up to 6 mg/kg/day) in rats on a low salt diet to enhance susceptibility [3]. Related Catalog Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection Natural Products >> Others References [1]. Hatanaka H, Kino T, Miyata S, FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1988 Nov;41(11):1592-601. [2]. Teutsch M, Higer M, Wang D, Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. Int Immunol. 1995 Mar;7(3):381-92. [3]. Mollison KW, Fey TA, Krause RA, Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. Toxicology. 1998 Feb 6;125(2-3):169-81. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 868.3±75.0 °C at 760 mmHg Melting Point 153-157ºC Molecular Formula C43H69NO12 Molecular Weight 792.008 Flash Point 478.9±37.1 °C Exact Mass 791.481995 PSA 178.36000 LogP 3.81 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.546 InChIKey ZDQSOHOQTUFQEM-JMVRLGAHSA-N SMILES CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC Storage condition −20°C Water Solubility Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water |
| Use of | Properties Articles28 Name ascomycin Synonym More Synonyms Ascomycin Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection Natural Products >> Others References [1]. Hatanaka H, Kino T, Miyata S, FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1988 Nov;41(11):1592-601. [2]. Teutsch M, Higer M, Wang D, Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. Int Immunol. 1995 Mar;7(3):381-92. [3]. Mollison KW, Fey TA, Krause RA, Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models. Toxicology. 1998 Feb 6;125(2-3):169-81. Chemical & Physical Properties Molecular Formula C43H69NO12 Exact Mass 791.481995 PSA 178.36000 Index of Refraction 1.546 InChIKey ZDQSOHOQTUFQEM-JMVRLGAHSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1648 International Maritime Transport Danger Regulations: 1648 International Air Transport Danger Regulations: 1648 14.2 United Nations shipping name European land transport hazard code: ACETONITRILE, solution IMDG Code: ACETONITRILE, solution IMDG: Acetonitrile, solution 14.3 Transport hazard categories European land transport Dangerous Regulations: 3 International sea transport Dangerous Regulations: 3 International air transport Dangerous Regulations: 3 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 6-O-alpha-Maltosyl-beta-cyclodextrin | 104723-60-6 | 2A-9050137 |
| 3-Hexyltetrahydro-4-hydroxy-6-undecyl-2H-pyran-2-one | 104801-96-9 | 2A-9050139 |
| 2-Nitrophenyl palmitate | 104809-26-9 | 2A-9050140 |
| Dihydroethidium | 104821-25-2 | 2A-9050143 |
| Methyl 3-bromo-4-methylbenzoate | 104901-43-1 | 2A-9050148 |
| Minamestane | 105051-87-4 | 2A-9050158 |
| cis-4-Phenylthio-L-proline hydrochloride | 105107-84-4 | 2A-9050162 |
| 4,4'-Bis(3-aminophenoxy)biphenyl | 105112-76-3 | 2A-9050163 |
| 3-[N-Tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic acid sodium salt | 105140-25-8 | 2A-9050164 |
| 3,3-Dimethoxy-2-(hydroxymethylene)propionitrile sodium salt | 105161-33-9 | 2A-9050166 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS