CAS Number99291-25-5
Synonyms(S)-dropropizine; Levdropropizina; 1,2-Propanediol,3-(4-phenyl-1-piperazinyl)-,(R); (-)-Dropropizine; rapitux; (+)-Dropropizine; (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol; (R)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol; Levdropropizina [Latin,Spanish]; (2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol; (R)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol; Levodropropizine; Dropropizine S-form
Molecular FormulaC13H20N2O2
Molecular Weight236.31
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point412.7±34.0 °C at 760 mmHg
Melting Point102-106ºC
Appearancewhite crystal powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 99291-25-5 |
| Catalog No. | 2A-9049601 |
| Chinese Name | 左羟丙哌嗪 |
| Synonyms | (S)-dropropizine; Levdropropizina; 1,2-Propanediol,3-(4-phenyl-1-piperazinyl)-,(R); (-)-Dropropizine; rapitux; (+)-Dropropizine; (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol; (R)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol; Levdropropizina [Latin,Spanish]; (2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol; (R)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol; Levodropropizine; Dropropizine S-form |
| Molecular Formula | C13H20N2O2 |
| Molecular Weight | 236.31 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 412.7±34.0 °C at 760 mmHg |
| Melting Point | 102-106ºC |
| Appearance | white crystal powder |
| Storage Condition | Refrigerator |
| Application | Levodropropizine (DF-526) is a histamine receptor inhibitor. Levodropropizine (DF-526) is an effective, well-tolerated antitussive. |
| HTC | 2933599090 |
| PubChem ID | 8189990 |
| SMILES | OCC(O)CN1CCN(c2ccccc2)CC1 |
| InChI | InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1 |
| InChI Key | PTVWPYVOOKLBCG-ZDUSSCGKSA-N |
| Use of | Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug. Properties Articles25 Name levodropropizine Synonym More Synonyms Levodropropizine Biological Activity Description Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Zanasi A, et al. Levodropropizine for treating cough in adult and children: a meta-analysis of published studies. Multidiscip Respir Med. 2015 May 31;10(1):19. Chemical & Physical Properties Molecular Formula C13H20N2O2 Exact Mass 236.152481 PSA 46.94000 Index of Refraction 1.577 InChIKey PTVWPYVOOKLBCG-ZDUSSCGKSA-N Storage condition Refrigerator Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1,2-Propanediol, 3-(4-phenylpiperazin-1-yl)-, S(-)- CAS REGISTRY NUMBER : 99291-25-5 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C13-H20-N2-O2 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988 Safety Information HS Code 2933599090 Synthetic Route Total: 1 Page 1-Phenylpiperazine CAS#:92-54-6 Levodropropizine CAS#:99291-25-5 Literature: US4699911 A1, ; 1-Phenylpiperazine CAS#:92-54-6 [(2S)-2,3-dihyd... CAS#:50765-70-3 Levodropropizine CAS#:99291-25-5 Literature: Giani; Marinone; Melillo; Borsa; Tonon Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 8 p. 1139 - 1141 1-Phenylpiperazine CAS#:92-54-6 (S)-Glycidyl to... CAS#:70987-78-9 Levodropropizine CAS#:99291-25-5 Literature: Arzneimittel-Forschung/Drug Research, , vol. 38, # 8 p. 1139 - 1141 Precursor & DownStream Precursor 3 CAS#:92-54-6 1-Phenylpiperazine CAS#:50765-70-3 [(2S)-2,3-dihyd... CAS#:70987-78-9 (S)-Glycidyl to... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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