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Mildronate dihydrate structure, CAS 86426-17-7

Mildronate dihydrate

CAS Number86426-17-7

Synonyms3-(2,2,2-Trimethylhydrazinium)propionate dihydrate; Diazanium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt, hydrate (1:2); Mildronatedehydrate; 3-(2,2,2-Trimethyldiazan-2-ium-1-yl)propanoate dihydrate; Mildronate

Molecular FormulaC6H18N2O4

Molecular Weight182.22

Purity98.00%

Density

Boiling Point

Melting Point

Flash Point

Appearancewhite to off-white

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9049361 Purity: 98.00%
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Quality Control of [ 86426-17-7 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number86426-17-7
Catalog No.2A-9049361
Chinese Name米屈肼(二水合物)
Synonyms3-(2,2,2-Trimethylhydrazinium)propionate dihydrate; Diazanium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt, hydrate (1:2); Mildronatedehydrate; 3-(2,2,2-Trimethyldiazan-2-ium-1-yl)propanoate dihydrate; Mildronate
Molecular FormulaC6H18N2O4
Molecular Weight182.22
Purity98.00
Appearancewhite to off-white
Water SolubilityH2O: >40mg/mL
Storage Condition2-8°C
ApplicationMildronate dihydrate (Meldonium dihydrate) is a cardiovascular protective drug that competitively inhibits BBOX1 and OCTN2. Mildronate (Meldonium) has an IC50 value of 34-62 μM for human recombinant B
PubChem ID329831532
MDL NumberMFCD00876389
SMILESC[N+](C)(C)NCCC([O-])=O
InChI1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
InChI KeyPVBQYTCFVWZSJK-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbolstransportation
MSDSmsds/49361_1_86426_17_7.pdf
BioactivityMildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Target IC50: 34-62 μM (human recombinant BBOX). EC50: 21 μM (human OCTN2). References [1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780. [2]. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25. Chemical & Physical Properties Molecular Formula C6H18N2O4 Molecular Weight 182.218 Exact Mass 182.126663 PSA 70.62000 Appearance of Characters white to off-white InChIKey JFWLFLLRLZSBRA-UHFFFAOYSA-N SMILES C[N+](C)(C)NCCC(=O)[O-].O.O Storage condition 2-8°C Water Solubility H2O: >40mg/mL
Use ofMildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1]. Properties Name Mildronate dihydrate Synonym More Synonyms Mildronate Biological Activity Description Mildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease IC50: 34-62 μM (human recombinant BBOX). EC50: 21 μM (human OCTN2). References [1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780. [2]. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25. Chemical & Physical Properties Molecular Formula C6H18N2O4 Exact Mass 182.126663 PSA 70.62000 Appearance of Characters white to off-white InChIKey JFWLFLLRLZSBRA-UHFFFAOYSA-N SMILES C[N+](C)(C)NCCC(=O)[O-].O.O
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip.
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