CAS Number77449-94-6
Synonyms(4R)-4-Hydroxy-D-proline hydrochloride (1:1); (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride; D-Proline, 4-hydroxy-, (4R)-, hydrochloride (1:1)
Molecular FormulaC5H10ClNO3
Molecular Weight167.59
Purity98.00%
Boiling Point368.6ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 77449-94-6 |
| Catalog No. | 2A-9048120 |
| Chinese Name | 顺式-4-羟基- D-脯氨酸盐酸盐 |
| Synonyms | (4R)-4-Hydroxy-D-proline hydrochloride (1:1); (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride; D-Proline, 4-hydroxy-, (4R)-, hydrochloride (1:1) |
| Molecular Formula | C5H10ClNO3 |
| Molecular Weight | 167.59 |
| Purity | 98.00 |
| Boiling Point | 368.6ºC at 760 mmHg |
| Storage Condition | 2~8℃ |
| Application | Cis-4-hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADC). Cis-4-hydroxy-D-proline hydrochloride is also a PROTAC linker based on alky |
| HTC | 2933990090 |
| PubChem ID | 28674294 |
| SMILES | Cl.O=C(O)C1CC(O)CN1 |
| InChI | InChI=1S/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/m1./s1 |
| InChI Key | YEJFFQAGTXBSTI-VKKIDBQXSA-N |
| Bioactivity | cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Boiling Point 368.6ºC at 760 mmHg Molecular Formula C5H10ClNO3 Molecular Weight 167.591 Exact Mass 167.034927 PSA 69.56000 InChIKey YEJFFQAGTXBSTI-VKKIDBQXSA-N SMILES Cl.O=C(O)C1CC(O)CN1 Storage condition 2~8℃ |
| Use of | cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Properties Name cis-4-Hydroxy-D-proline Hydrochloride Synonym More Synonyms Biological Activity Description cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Exact Mass 167.034927 PSA 69.56000 InChIKey YEJFFQAGTXBSTI-VKKIDBQXSA-N Storage condition 2~8℃ |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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