CAS Number72432-10-1
SynonymsMFCD00153767; Ro 13-5057; Aniracetam; 1-p-Anisoyl-2-pyrrolidinone; Sarpul; 1-(4-Methoxybenzoyl)pyrrolidin-2-one; Ampamet; Draganon; 1-[(4-Methoxyphenyl)carbonyl]pyrrolidin-2-on; 1-anisoyl-2-pyrrolidinone; 1-(4-Methoxybenzoyl)-2-pyrrolidinone; 1-[(4-Methoxyphenyl)carbonyl]pyrrolidin-2-one
Molecular FormulaC12H13NO3
Molecular Weight219.24
Purity≥99 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point399.7±34.0 °C at 760 mmHg
Melting Point−58 °C(lit.)
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 72432-10-1 |
| Catalog No. | 2A-9047447 |
| Chinese Name | 阿尼西坦 |
| Synonyms | MFCD00153767; Ro 13-5057; Aniracetam; 1-p-Anisoyl-2-pyrrolidinone; Sarpul; 1-(4-Methoxybenzoyl)pyrrolidin-2-one; Ampamet; Draganon; 1-[(4-Methoxyphenyl)carbonyl]pyrrolidin-2-on; 1-anisoyl-2-pyrrolidinone; 1-(4-Methoxybenzoyl)-2-pyrrolidinone; 1-[(4-Methoxyphenyl)carbonyl]pyrrolidin-2-one |
| Molecular Formula | C12H13NO3 |
| Molecular Weight | 219.24 |
| Purity | ≥99 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 399.7±34.0 °C at 760 mmHg |
| Melting Point | −58 °C(lit.) |
| Appearance | solid |
| Water Solubility | Reacts |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | Aniracetam (Ro 13-5057) can regulate AMPA receptors and nAChR, and has neuroprotective and nootropic effects. |
| PubChem ID | 586099 |
| MDL Number | MFCD00153767 |
| SMILES | N2(CCCC2=O)C(=O)c1ccc(cc1)OC |
| InChI | 1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3 |
| InChI Key | ZXNRTKGTQJPIJK-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/47447_1_72432_10_1.pdf |
| Bioactivity | Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.Target: AMPA; nAChRAniracetam is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It selectively modulates the AMPA receptor. It is lipid soluble and has possible cognition enhancing effects. It has been tested in animals extensively, Alzheimer's patients and temporarily-impaired healthy subjects. It has shown potential as an anxiolytic in three clinical animal models [1].Administration of aniracetam for 10 days (post-natal days (PND) 18-27), at a dose of 50 mg/kg reversed cognitive deficits in both rat genders, indicated by a significant increase in the number of avoidances and the number of 'good learners'. After the termination of the nootropic treatment, a significant increase in both amplitude and frequency of AMPA receptor-mediated mEPSCs in hippocampal CA-1 pyramidal cells was observed [2].Clinical indications: Cognitive disorder; StrokeFDA Approved Date: Toxicity: insomnia; headaches; nausea or rash. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease References [1]. Nakamura K, et al. Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43. [2]. Vaglenova J, et al. Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. Neuropsychopharmacology. 2008 Apr;33(5):1071-83. Epub 2007 Jul 4. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 399.7±34.0 °C at 760 mmHg Melting Point −58 °C(lit.) Molecular Formula C12H13NO3 Molecular Weight 219.236 Flash Point 195.5±25.7 °C Exact Mass 219.089539 PSA 46.61000 LogP 0.27 Vapour density 4.9 (vs air) Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.574 InChIKey ZXNRTKGTQJPIJK-UHFFFAOYSA-N SMILES COc1ccc(C(=O)N2CCCC2=O)cc1 Storage condition Store at RT Water Solubility Reacts |
| Use of | Properties Articles32 Name aniracetam Synonym More Synonyms Aniracetam Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease References [1]. Nakamura K, et al. Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43. [2]. Vaglenova J, et al. Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. Neuropsychopharmacology. 2008 Apr;33(5):1071-83. Epub 2007 Jul 4. Chemical & Physical Properties Molecular Formula C12H13NO3 Exact Mass 219.089539 PSA 46.61000 Vapour density 4.9 (vs air) Index of Refraction 1.574 InChIKey ZXNRTKGTQJPIJK-UHFFFAOYSA-N Storage condition Store at RT Water Solubility Reacts |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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