CAS Number1092939-17-7
Synonyms(3R)-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propionitrile phosphate; (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate; Ruxolitinib phosphate; Jakafi; Ruxolitinib (phosphate)
Molecular FormulaC17H21O4N6P1
Molecular Weight404.37
Purity98.00%
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1092939-17-7 |
| Catalog No. | 2A-9047174 |
| Chinese Name | 鲁索利替尼磷酸盐 |
| Synonyms | (3R)-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propionitrile phosphate; (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate; Ruxolitinib phosphate; Jakafi; Ruxolitinib (phosphate) |
| Molecular Formula | C17H21O4N6P1 |
| Molecular Weight | 404.37 |
| Purity | 98.00 |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Ruxolitinib phosphate is a potent JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM respectively, which is 130 times more selective than JAK3. |
| HTC | 2933990090 |
| PubChem ID | 56451385 |
| MDL Number | MFCD18452860 |
| SMILES | N#CCC(C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1.O=P(O)(O)O |
| InChI | InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1 |
| InChI Key | JFMWPOCYMYGEDM-XFULWGLBSA-N |
| MSDS | msds/47174_1_1092939_17_7.pdf |
| Use of | Properties Name ruxolitinib phosphate Synonym More Synonyms Ruxolitinib phosphate Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Cancer JAK2:2.8 nM (IC50) JAK1:3.3 nM (IC50) Tyk2:19 nM (IC50) JAK3:428 nM (IC50) In Vitro Ruxolitinib (INCB018424) potently and selectively inhibits JAK2V617F-mediated signaling and proliferation. Ruxolitinib inhibits the growth of HEL cells with EC50 of 186 nM. Ruxolitinib markedly increases apoptosis in Ba/F3-EpoR-JAK2V617F cell system, and inhibits hematopoietic progenitor cell proliferation in primary MPN patient samples[1]. Animal Admin Mice are fed standard rodent chow and provided with water ad libitum. Ba/F3-JAK2V617F cells (105 per mouse) are inoculated intravenously into 6- to 8-week-old female BALB/c mice. Survival is monitored daily, and moribund mice are humanely killed and considered deceased at time of death. Treatment with vehicle (5% dimethyl acetamide, 0.5% methocellulose) or Ruxolitinib (INCB018424) begins within 24 hours of cell inoculation, twice daily by oral gavage. Hematologic parameters are measured using a Bayer Advia120 analyzed, and statistical significance is determined using Dunnett testing. References [2]. Fleischman AG, et al. The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition. Blood. 2013 Nov 21;122(22):3628-31. Chemical & Physical Properties Molecular Formula C17H21N6O4P Exact Mass 404.136200 PSA 170.75000 LogP 2.53778 InChIKey JFMWPOCYMYGEDM-XFULWGLBSA-N Storage condition -20℃ Safety Information Hazard Codes N HS Code 2933990090 Synthetic Route Ruxolitinib (IN... CAS#:941678-49-5 Ruxolitinib pho... CAS#:1092939-17-7 INCB032304 CAS#:941685-27-4 Ruxolitinib pho... CAS#:1092939-17-7 (2E)-3-Cyclopen... CAS#:591769-05-0 Ruxolitinib pho... CAS#:1092939-17-7 Precursor & DownStream Precursor 3 CAS#:941678-49-5 Ruxolitinib (IN... CAS#:941685-27-4 INCB032304 CAS#:591769-05-0 (2E)-3-Cyclopen... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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