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(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride

Name: (6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
Brand: 2A Biotech
SKU: 2A-9046966

CAS Number69056-38-8

Synonyms(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride; (6R,1'R,2'S)-6-(1',2'-dihydroxypropyl)-5,6,7,8-tetrahydrobiopterin; Dapropterin; (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-pteridinone; (6R)-5,6,7,8-tetrahydro-L-biopterin; (6R)-Tetrahydrobiopterin; 6R-tetahydrobiopterin; Dapropterin dihydrochloride; Biopten; (6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE; sapropterinum; (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one; R-THBP; MFCD00891665; (R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride; (6R)-5,6,7,8-Tetrahydrobiopterin; (6R)-tetrahydrobiopterin dihydrochloride; [6R-[6R*(1R*,2S*)]]-2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrah

Molecular FormulaC9H17Cl2N5O3

Molecular Weight314.17

Purity98.00%

Density1.9±0.1 g/cm3

Boiling Point506.6±60.0 °C at 760 mmHg

MSDSChinese English

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Cat. No.: 2A-9046966 Purity: 98.00%

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Quality Control of [ 69056-38-8 ] Purity: 98.00% SDS Specification MoL

Chemical & Physical Properties
CAS Number	69056-38-8
Catalog No.	2A-9046966
Chinese Name	(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐
Synonyms	(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride; (6R,1'R,2'S)-6-(1',2'-dihydroxypropyl)-5,6,7,8-tetrahydrobiopterin; Dapropterin; (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-pteridinone; (6R)-5,6,7,8-tetrahydro-L-biopterin; (6R)-Tetrahydrobiopterin; 6R-tetahydrobiopterin; Dapropterin dihydrochloride; Biopten; (6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE; sapropterinum; (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one; R-THBP; MFCD00891665; (R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride; (6R)-5,6,7,8-Tetrahydrobiopterin; (6R)-tetrahydrobiopterin dihydrochloride; [6R-[6R(1R,2S*)]]-2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrah
Molecular Formula	C9H17Cl2N5O3
Molecular Weight	314.17
Purity	98.00
Density	1.9±0.1 g/cm3
Boiling Point	506.6±60.0 °C at 760 mmHg
Storage Condition	Store in an airtight container at -20ºC.
Application	Sapropterin dihydrochloride is a synthetic form of BH4 approved for the treatment of BH4-reactive PKU.
HTC	2933990090
PubChem ID	24277922
MDL Number	MFCD00891665
SMILES	Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2=C(N1)C(=O)NC(N)=N2
InChI	1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
InChI Key	RKSUYBCOVNCALL-NTVURLEBSA-N
NACRES Code	NA.77
UNSPSC	12352200
Hazard Symbols	transportation
MSDS	msds/46966_1_69056_38_8.pdf
Bioactivity	Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU. (1) Sapropterin dihydrochloride can stimulate TH and TPH activities leading to improved dopamine and serotonin synthesis despite persistently elevated brain phenylalanine.(2) Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease Natural Products >> Alkaloid References [1]. Winn SR et al. High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU). Mol Genet Metab. 2016 Jan;117(1):5-11. [2]. Somaraju UR et al. Sapropterin dihydrochloride for phenylketonuria. Cochrane Database Syst Rev. 2015 Mar 27 [3]. Jurecki ER et al. Sapropterin Dihydrochloride Mixed With Common Foods and Beverages. Top Clin Nutr. 2014 Oct;29(4):325-331. [4]. Grange DK et al. Sapropterin dihydrochloride use in pregnant women with phenylketonuria: an interim report of the PKU MOMS sub-registry. Mol Genet Metab. 2014 May;112(1):9-16 Chemical & Physical Properties Density 1.9±0.1 g/cm3 Boiling Point 506.6±60.0 °C at 760 mmHg Molecular Formula C9H17Cl2N5O3 Molecular Weight 314.17 Flash Point 260.2±32.9 °C PSA 136.29000 LogP -4.22 Vapour Pressure 0.0±3.0 mmHg at 25°C Index of Refraction 1.822 InChIKey RKSUYBCOVNCALL-NTVURLEBSA-N SMILES CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1.Cl.Cl Storage condition −20°C
Use of	Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU. (1) Sapropterin dihydrochloride can stimulate TH and TPH activities leading to improved dopamine and serotonin synthesis despite persistently elevated brain phenylalanine.(2) Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. Properties Name sapropterin dihydrochloride Synonym More Synonyms Biological Activity Description Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU. (1) Sapropterin dihydrochloride can stimulate TH and TPH activities leading to improved dopamine and serotonin synthesis despite persistently elevated brain phenylalanine.(2) Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease Natural Products >> Alkaloid References [1]. Winn SR et al. High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU). Mol Genet Metab. 2016 Jan;117(1):5-11. [2]. Somaraju UR et al. Sapropterin dihydrochloride for phenylketonuria. Cochrane Database Syst Rev. 2015 Mar 27 [3]. Jurecki ER et al. Sapropterin Dihydrochloride Mixed With Common Foods and Beverages. Top Clin Nutr. 2014 Oct;29(4):325-331. [4]. Grange DK et al. Sapropterin dihydrochloride use in pregnant women with phenylketonuria: an interim report of the PKU MOMS sub-registry. Mol Genet Metab. 2014 May;112(1):9-16 Chemical & Physical Properties PSA 136.29000 LogP -4.22 Index of Refraction 1.822 InChIKey RKSUYBCOVNCALL-NTVURLEBSA-N
Tax Rebate	13.0%
Supervision	None. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport Info	Shipping Name: UN
MSDS Transport Info	Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available

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(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride

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