CAS Number67920-52-9
SynonymsSodium 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate; 3-(3',4'-Dihydroxyphenyl)lactic acid sodium salt; Benzenepropanoic acid, α,3,4-trihydroxy-, sodium salt (1:1); Danshensu (sodium salt)
Molecular FormulaC9H9NaO5
Molecular Weight220.15
Purity≥95.0 (HPLC)%
Appearancesolid
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 67920-52-9 |
| Catalog No. | 2A-9046672 |
| Chinese Name | 丹参素钠 |
| Synonyms | Sodium 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate; 3-(3',4'-Dihydroxyphenyl)lactic acid sodium salt; Benzenepropanoic acid, α,3,4-trihydroxy-, sodium salt (1:1); Danshensu (sodium salt) |
| Molecular Formula | C9H9NaO5 |
| Molecular Weight | 220.15 |
| Purity | ≥95.0 (HPLC) |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | Danshensu is derived from the Chinese herb Salvia miltiorrhiza, which inhibits CaCl2-induced vasoconstriction. |
| PubChem ID | 15172123 |
| MDL Number | MFCD09037393 |
| SMILES | [Na+].[O-]c1c(cc(cc1)CC(O)C(=O)O)O |
| InChI | 1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1 |
| InChI Key | ZMMKVDBZTXUHFO-UHFFFAOYSA-M |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/46672_1_67920_52_9.pdf |
| Bioactivity | Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.[1]In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.[2] Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Others Natural Products >> Phenylpropanoids References [1]. Zhang N. Biphasic effects of sodium danshensu on vessel function in isolated rat aorta. Acta Pharmacol Sin, 2010 Apr, 31(4):421-8. [2]. Tian Wang et al. Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation. J Neuroimmunol, 2012 Apr, 245(1-2):79-86. Chemical & Physical Properties Molecular Formula C9H9NaO5 Molecular Weight 220.154 Exact Mass 220.034775 PSA 100.82000 Storage condition 2-8°C |
| Use of | Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.[1]In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.[2] Properties Name Sodium danshensu Synonym More Synonyms Sodium Danshensu Biological Activity Description Danshensu (sodium salt) is odium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.In vitro: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells.[1]In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.[2] Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Others Natural Products >> Phenylpropanoids References [1]. Zhang N. Biphasic effects of sodium danshensu on vessel function in isolated rat aorta. Acta Pharmacol Sin, 2010 Apr, 31(4):421-8. [2]. Tian Wang et al. Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation. J Neuroimmunol, 2012 Apr, 245(1-2):79-86. Chemical & Physical Properties Molecular Formula C9H9NaO5 Exact Mass 220.034775 PSA 100.82000 |
| Transport Info | Product Name: Sodium Danshensu |
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