| Chemical & Physical Properties | |
|---|---|
| CAS Number | 67915-31-5 |
| Catalog No. | 2A-9046671 |
| Chinese Name | 曲康唑 |
| Synonyms | Terconagole; MFCD05662369; Fungistat; EINECS 267-751-6; Triaconazole |
| Molecular Formula | C26H31Cl2N5O3 |
| Molecular Weight | 532.46 |
| Purity | 98.00 |
| Density | 1.35g/cm3 |
| Boiling Point | 681.8ºC at 760mmHg |
| Melting Point | 126.3ºC |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Terconazole is a broad-spectrum antifungal drug used to treat vaginal yeast infections. |
| PubChem ID | 10280 |
| SMILES | CC(C)N1CCN(c2ccc(OCC3COC(Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 |
| InChI | InChI=1S/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/m0/s1 |
| InChI Key | BLSQLHNBWJLIBQ-OZXSUGGESA-N |
| Hazard Symbols | transportation |
| Bioactivity | Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection. Related Catalog Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection In Vitro Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 0.1 to 10 μM when the yeast is grown on media favoring the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1 μM terconazole through complete necrosis at 100 μM[1]. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL[2]. In Vivo A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days because of prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole[2]. Animal Admin Rats: The rats are infected intravaginally with C. albicans. They are treated topically twice daily for 3 days, starting 24 hours after infection with a volume of 0.2 mL of various concentrations of terconazole (0.125%, 0.25%, 0.4%, 0.5%, 1%, 2%), miconazole, clotrimazole, econazole, nystatin, or amphotericin B[2]. References [1]. Tolman EL, et al. Anticandidal activities of terconazole, a broad-spectrum antimycotic. Antimicrob Agents Chemother. 1986 Jun;29(6):986-91. [2]. Van Cutsem J, et al. The in vitro activity of terconazole against yeasts: its topical long-acting therapeutic efficacy in experimental vaginal candidiasis in rats. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1200-6. Chemical & Physical Properties Density 1.35g/cm3 Boiling Point 681.8ºC at 760mmHg Melting Point 126.3ºC Molecular Formula C26H31Cl2N5O3 Molecular Weight 532.46200 Flash Point 366.2ºC Exact Mass 531.18000 PSA 64.88000 LogP 4.46560 Index of Refraction 1.64 InChIKey BLSQLHNBWJLIBQ-OZXSUGGESA-N SMILES CC(C)N1CCN(c2ccc(OCC3COC(Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 Storage condition 2-8°C |
| Use of | Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection. Properties Articles34 Name Terconazole Synonym More Synonyms Terconazole Biological Activity Description Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection. Related Catalog Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection In Vivo A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days because of prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole[2]. References [1]. Tolman EL, et al. Anticandidal activities of terconazole, a broad-spectrum antimycotic. Antimicrob Agents Chemother. 1986 Jun;29(6):986-91. [2]. Van Cutsem J, et al. The in vitro activity of terconazole against yeasts: its topical long-acting therapeutic efficacy in experimental vaginal candidiasis in rats. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1200-6. Chemical & Physical Properties Exact Mass 531.18000 PSA 64.88000 LogP 4.46560 Index of Refraction 1.64 InChIKey BLSQLHNBWJLIBQ-OZXSUGGESA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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