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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt
4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt structure, CAS 65664-81-5

4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt

CAS Number65664-81-5

SynonymsBIS-ANS; BIS-ANS DIPOTASSIUM SALT; 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt; 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID,POTASSIUM SALT; potassium 8,8'-dianilino-5,5'-binaphthalene-1,1'-disulfonate; 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid,dipot; 8-Anilino-1-naphthalenesulfonic Acid Di; 4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A; 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISU LFONIC ACI

Molecular FormulaC32H22K2N2O6S2

Molecular Weight672.85300

Purity98.00%

Density

Boiling Point

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Cat. No.: 2A-9046305 Purity: 98.00%
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Quality Control of [ 65664-81-5 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number65664-81-5
Catalog No.2A-9046305
Chinese Name4,4'-二苯胺基-1,1'-联萘-5,5'-二磺酸二钾盐
SynonymsBIS-ANS; BIS-ANS DIPOTASSIUM SALT; 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt; 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID,POTASSIUM SALT; potassium 8,8'-dianilino-5,5'-binaphthalene-1,1'-disulfonate; 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid,dipot; 8-Anilino-1-naphthalenesulfonic Acid Di; 4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A; 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISU LFONIC ACI
Molecular FormulaC32H22K2N2O6S2
Molecular Weight672.85300
Purity98.00
ApplicationBis-ANS dipotassium is a protein fluorescent probe that binds to tubulin with a Kd of 2 μM. Bis-ANS dipotassium is an effective biphasic modulator for protein liquid-liquid phase separation (LLPS). Bi
PubChem ID24893823
SMILESO=S(=O)([O-])c1cccc2c(-c3ccc(Nc4ccccc4)c4c(S(=O)(=O)[O-])cccc34)ccc(Nc3ccccc3)c12.[K+].[K+]
InChIInChI=1S/C32H24N2O6S2.2K/c35-41(36,37)29-15-7-13-25-23(17-19-27(31(25)29)33-21-9-3-1-4-10-21)24-18-20-28(34-22-11-5-2-6-12-22)32-26(24)14-8-16-30(32)42(38,39)40;;/h1-20,33-34H,(H,35,36,37)(H,38,39,40);;/q;2*+1/p-2
InChI KeyVWLWTJHKQHRTNC-UHFFFAOYSA-L
Hazard Symbolstransportation
BioactivityBis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Neurological Disease In Vitro Bis-ANS is a fluorescent molecule that has been used to probe exposed hydrophobic patches in proteins and to monitor the formation of protein aggregates. Bis-ANS is a bivalent naphthalene sulfonate with aniline moieties. Bis-ANS modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD)[2]. References [1]. P Horowitz, et al. Bis(1,8-anilinonaphthalenesulfonate). A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259(23):14647-50. [2]. W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020) Chemical & Physical Properties Molecular Formula C32H22K2N2O6S2 Molecular Weight 672.85300 Exact Mass 672.01900 PSA 155.22000 LogP 9.26300 InChIKey VWLWTJHKQHRTNC-UHFFFAOYSA-L SMILES O=S(=O)([O-])c1cccc2c(-c3ccc(Nc4ccccc4)c4c(S(=O)(=O)[O-])cccc34)ccc(Nc3ccccc3)c12.[K+].[K+]
Use ofBis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2]. Properties Name Bis-ANS,4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt Synonym More Synonyms Bis-ANS dipotassium Biological Activity Description Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Neurological Disease References [1]. P Horowitz, et al. Bis(1,8-anilinonaphthalenesulfonate). A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259(23):14647-50. [2]. W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020) Chemical & Physical Properties Molecular Formula C32H22K2N2O6S2 Exact Mass 672.01900 PSA 155.22000 LogP 9.26300 InChIKey VWLWTJHKQHRTNC-UHFFFAOYSA-L
Transport InfoProduct name: Purity: 95.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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