CAS Number65576-45-6
Synonyms(3aS,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole; Saphris; L-Ascorbic Acid 6-Palmitate; trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole; scorbicpalmitate; Vitamin C Palmitate; 6-palmitoylascorbic acid; Asenapine; trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine
Molecular FormulaC17H16O1N1Cl1
Molecular Weight285.77
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point357.9±42.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 65576-45-6 |
| Catalog No. | 2A-9046297 |
| Chinese Name | 阿塞那平 |
| Synonyms | (3aS,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole; Saphris; L-Ascorbic Acid 6-Palmitate; trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole; scorbicpalmitate; Vitamin C Palmitate; 6-palmitoylascorbic acid; Asenapine; trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine |
| Molecular Formula | C17H16O1N1Cl1 |
| Molecular Weight | 285.77 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 357.9±42.0 °C at 760 mmHg |
| Storage Condition | Store at +4°C |
| Application | Asenapine (Org 5222) can inhibit adrenergic receptors, with a Ki of 0.25-1.2 nM for α1, α2A, α2B and α2C, and also inhibits 5-HT receptors, with a Ki of 0.03-4.0 nM for 1A, 1B, 2A, 2B, 2C, 5A, 6 and 7 |
| HTC | 2934999090 |
| PubChem ID | 10255109 |
| MDL Number | MFCD00869603 |
| SMILES | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 |
| InChI | InChI=1S/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/m1/s1 |
| InChI Key | VSWBSWWIRNCQIJ-GJZGRUSLSA-N |
| MSDS | msds/46297_1_65576_45_6.pdf |
| Use of | Properties Name Asenapine Synonym More Synonyms Asenapine Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease References [1]. Stoner SC, Pace HA. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34(5):1023-40. [2]. Tarazi FI, Shahid M. Asenapine maleate: a new drug for the treatment of schizophrenia and bipolar mania. Drugs Today (Barc). 2009 Dec;45(12):865-76. [3]. Elsworth JD, Groman SM, Jentsch JD et al. Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology. 2012 Mar;62(3):1442-52. [4]. Potkin SG. Asenapine: a clinical overview. J Clin Psychiatry. 2011;72 Suppl 1:14-8. [5]. Shahid M, Walker GB, Zorn SH, Wong EH. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [6]. Asenapine Chemical & Physical Properties Exact Mass 285.092041 PSA 12.47000 Index of Refraction 1.610 InChIKey VSWBSWWIRNCQIJ-GJZGRUSLSA-N Safety Information HS Code 2934999090 Synthetic Route trans-(±)-11-... 129385-59-7 65576-45-6 Asenapine Malea... 85650-56-2 65576-45-6 2-Chlorophenyla... 65576-45-6 Precursor & DownStream Precursor 10 CAS#:129385-59-7 trans-(±)-11-... CAS#:85650-56-2 Asenapine Maleate CAS#:2444-36-2 2-Chlorophenyla... CAS#:57486-68-7 Methyl (2-chlor... DownStream 2 CAS#:85650-56-2 Asenapine Maleate CAS#:128915-56-0 N-desmethylasenapine |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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