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1alpha,25-Dihydroxyvitamin D2 structure, CAS 60133-18-8

1alpha,25-Dihydroxyvitamin D2

CAS Number60133-18-8

Synonyms1α,25-dihydroxyergocalciferol; 1alpha,25-dihydroxyvitamin D2; 1α,25-Dihydroxy Vitamin D2; (1S,3R,5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3,25-triol; 1α,25-Dihydroxycalciferol; Ercalcitriol

Molecular FormulaC28H44O3

Molecular Weight428.65

Purity98.00%

Density1.1±0.1 g/cm3

Boiling Point577.7±50.0 °C at 760 mmHg

Melting Point

Flash Point

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Cat. No.: 2A-9045294 Purity: 98.00%
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Quality Control of [ 60133-18-8 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number60133-18-8
Catalog No.2A-9045294
Chinese Name1α,25-二羟维生素 D2
Synonyms1α,25-dihydroxyergocalciferol; 1alpha,25-dihydroxyvitamin D2; 1α,25-Dihydroxy Vitamin D2; (1S,3R,5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3,25-triol; 1α,25-Dihydroxycalciferol; Ercalcitriol
Molecular FormulaC28H44O3
Molecular Weight428.65
Purity98.00
Density1.1±0.1 g/cm3
Boiling Point577.7±50.0 °C at 760 mmHg
Storage Condition−20°C
ApplicationErcalcitriol (1α,25-Dihydroxy Vitamin D2) is the active metabolite of vitamin D2.
PubChem ID329765370
SMILESC=C1C(=CC=C2CCCC3(C)C2CCC3C(C)C=CC(C)C(C)(C)O)CC(O)CC1O
InChIInChI=1S/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25+,26+,28-/m1/s1
InChI KeyZGLHBRQAEXKACO-XJRQOBMKSA-N
Hazard Symbolstransportation
BioactivityErcalcitriol (1α,25-Dihydroxy Vitamin D2) is a active metabolite of vitamin D2. IC50 value: Target: Ercalcitriol (1α,25-Dihydroxy Vitamin D2) exhibits equipotent antirachitic activity in rats as calcitriol. Ercalcitriol(1α,25-Dihydroxy Vitamin D2) is a VDR-like Receptors Related Catalog Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease References [1]. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209. [2]. Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135. [3]. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199 [4]. Daniel W. Coyne, Marvin Grieff, Shubhada N. Ahya et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients. American Journal of Kidney Diseases. December 2002,Volume 40, Issue 6 , Pages 1283-1288 Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 577.7±50.0 °C at 760 mmHg Molecular Formula C28H44O3 Molecular Weight 428.647 Flash Point 242.5±24.7 °C Exact Mass 428.329041 PSA 60.69000 LogP 6.15 Vapour Pressure 0.0±3.6 mmHg at 25°C Index of Refraction 1.554 InChIKey ZGLHBRQAEXKACO-XJRQOBMKSA-N SMILES C=C1C(=CC=C2CCCC3(C)C2CCC3C(C)C=CC(C)C(C)(C)O)CC(O)CC1O Storage condition −20°C
Use ofErcalcitriol (1α,25-Dihydroxy Vitamin D2) is a active metabolite of vitamin D2. IC50 value: Target: Ercalcitriol (1α,25-Dihydroxy Vitamin D2) exhibits equipotent antirachitic activity in rats as calcitriol. Ercalcitriol(1α,25-Dihydroxy Vitamin D2) is a VDR-like Receptors Properties Articles116 Name 1α,25-dihydroxyvitamin D2 Synonym More Synonyms 1-α,25-Dihydroxyvitamin D2 Biological Activity Description Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a active metabolite of vitamin D2. IC50 value: Target: Ercalcitriol (1α,25-Dihydroxy Vitamin D2) exhibits equipotent antirachitic activity in rats as calcitriol. Ercalcitriol(1α,25-Dihydroxy Vitamin D2) is a VDR-like Receptors Related Catalog Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease References [1]. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209. [2]. Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135. [3]. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199 [4]. Daniel W. Coyne, Marvin Grieff, Shubhada N. Ahya et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients. American Journal of Kidney Diseases. December 2002,Volume 40, Issue 6 , Pages 1283-1288 Chemical & Physical Properties Molecular Formula C28H44O3 Exact Mass 428.329041 PSA 60.69000 Index of Refraction 1.554 InChIKey ZGLHBRQAEXKACO-XJRQOBMKSA-N
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MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1170 International Maritime Transport Danger Regulations: 1170 International Air Transport Danger Regulations: 1170 14.2 United Nations shipping name European Land Transport Danger Regulations: ETHANOL SOLUTION International Maritime Dangerous Regulations: ETHANOL SOLUTION International Air Transport Danger Regulations: Ethanol solution 14.3 Transport hazard categories European land transport Dangerous Regulations: 3 International sea transport Dangerous Regulations: 3 International air transport Dangerous Regulations: 3 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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