CAS Number59643-91-3
SynonymsImexonum [INN-Latin]; Imexon; 4-Imino-1,3-diazabicyclo(3.1.0)hexan-2-one; 4-amino-1,3-diaza-bicyclo[3.1.0]hex-3-en-2-one; EINECS 261-838-2; (5RS)-4-amino-1,3-diazabicyclo[3.1.0]hex-3-en-2-one; 1,3 diaza 4 imino 2 oxobicyclo[3.1.0]hexane
Molecular FormulaC4H5N3O
Molecular Weight111.10200
Purity98.00%
Density2.26g/cm3
Boiling Point231.6ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 59643-91-3 |
| Catalog No. | 2A-9045209 |
| Chinese Name | 亚美克松 |
| Synonyms | Imexonum [INN-Latin]; Imexon; 4-Imino-1,3-diazabicyclo(3.1.0)hexan-2-one; 4-amino-1,3-diaza-bicyclo[3.1.0]hex-3-en-2-one; EINECS 261-838-2; (5RS)-4-amino-1,3-diazabicyclo[3.1.0]hex-3-en-2-one; 1,3 diaza 4 imino 2 oxobicyclo[3.1.0]hexane |
| Molecular Formula | C4H5N3O |
| Molecular Weight | 111.10200 |
| Purity | 98.00 |
| Density | 2.26g/cm3 |
| Boiling Point | 231.6ºC at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | Imexon is an aziridine compound with anti-cancer properties. |
| HTC | 2933990090 |
| PubChem ID | 455679 |
| SMILES | NC1=NC(=O)N2CC12 |
| InChI | InChI=1S/C4H5N3O/c5-3-2-1-7(2)4(8)6-3/h2H,1H2,(H2,5,6,8) |
| InChI Key | BIXBBIPTYBJTRY-UHFFFAOYSA-N |
| Use of | Imexon is an iminopyrrolidone aziridine with anti-cancer activity. Properties Name 2-amino-3,5-diazabicyclo[3.1.0]hex-2-en-4-one Synonym More Synonyms Imexon Biological Activity Description Imexon is an iminopyrrolidone aziridine with anti-cancer activity. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Cell Assay Cell survival for the siRNA screening experiments are calculated by the conversion of resazurin to resorufin by metabolically active cells resulting in a fluorescent product. Confirmatory growth inhibition assays with eIF2b silencing are done using the methyl-thiazolyl-diphenyl-tetrazolium bromide (MTT) assay. Cell growth inhibition data are expressed as percent survival, compared to untreated cells. The IC50 is defined as the drug concentration required to produce 50% growth inhibition. References [1]. Sheveleva EV, et al. Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells. Mol Cancer Res. 2012 Mar;10(3):392-400. [3]. Roman NO, et al. Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase. Cancer Chemother Pharmacol. 2011 Jan;67(1):183-92. Chemical & Physical Properties Molecular Formula C4H5N3O Exact Mass 111.04300 PSA 55.96000 Index of Refraction 2.069 InChIKey BIXBBIPTYBJTRY-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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