CAS Number56287-74-2
SynonymsArofuto; Aroft; Afloqualonum [INN-Latin]; Afloqualone; 6-amino-2-fluoromethyl-3-o-tolyl-3H-quinazolin-4-one; 6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone; 2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone; 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3H)-quinazolinone; 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one; MFCD00867693; Afloqualona [INN-Spanish]; HQ 495; Afloqualon; Afloqualone [INN:JAN]
Molecular FormulaC16H14FN3O
Molecular Weight283.308
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point492.5±55.0 °C at 760 mmHg
Melting Point195-196ºC
AppearanceWhite to light yellow crystal or crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56287-74-2 |
| Catalog No. | 2A-9044589 |
| Chinese Name | 氟喹酮 |
| Synonyms | Arofuto; Aroft; Afloqualonum [INN-Latin]; Afloqualone; 6-amino-2-fluoromethyl-3-o-tolyl-3H-quinazolin-4-one; 6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone; 2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone; 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3H)-quinazolinone; 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one; MFCD00867693; Afloqualona [INN-Spanish]; HQ 495; Afloqualon; Afloqualone [INN:JAN] |
| Molecular Formula | C16H14FN3O |
| Molecular Weight | 283.308 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 492.5±55.0 °C at 760 mmHg |
| Melting Point | 195-196ºC |
| Appearance | White to light yellow crystal or crystalline powder |
| Storage Condition | The warehouse is ventilated and dried at low tempe |
| Application | Afloqualone is a GABA_A receptor beta subtype agonist. |
| PubChem ID | 5597976 |
| MDL Number | MFCD00867693 |
| SMILES | Cc1ccccc1-n1c(CF)nc2ccc(N)cc2c1=O |
| InChI | InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3 |
| InChI Key | VDOSWXIDETXFET-UHFFFAOYSA-N |
| MSDS | msds/44589_1_56287_74_2.pdf |
| Bioactivity | Afloqualone is a agonist of GABA receptor .Target: GABA Receptorin vitro: Afloqualone is a quinazolinone family GABAergic drug.Afloqualone is an analogue of methaqualone. It has sedative and muscle-relaxant effects, resulting from its agonist activity at the β subtype of the GABAa receptor.in vivo: Afloqualone slightly increased the response during the alarm period in one out of 3 rats at 5, 10, and 20 mg/kg p.o., respectively. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Yamamura M, et al. Effects of afloqualone, a new centrally acting muscle relaxant, on DRL response and CER in rats (author's transl). Nihon Yakurigaku Zasshi. 1981 Oct;78(4):381-92. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 492.5±55.0 °C at 760 mmHg Melting Point 195-196ºC Molecular Formula C16H14FN3O Molecular Weight 283.300 Flash Point 251.7±31.5 °C Exact Mass 283.112091 PSA 60.91000 LogP 1.28 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.642 InChIKey VDOSWXIDETXFET-UHFFFAOYSA-N SMILES Cc1ccccc1-n1c(CF)nc2ccc(N)cc2c1=O |
| Use of | Properties Name 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one Synonym More Synonyms Afloqualone Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Yamamura M, et al. Effects of afloqualone, a new centrally acting muscle relaxant, on DRL response and CER in rats (author's transl). Nihon Yakurigaku Zasshi. 1981 Oct;78(4):381-92. Chemical & Physical Properties Molecular Formula C16H14FN3O Exact Mass 283.112091 PSA 60.91000 Index of Refraction 1.642 InChIKey VDOSWXIDETXFET-UHFFFAOYSA-N |
| Transport Info | Product Name: Fluoroquinone |
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