CAS Number53213-82-4
SynonymsMFCD00011954; DiOC6(3) [3,3'-Dihexyloxacarbocyanine iodide]; 3-hexyl-2-[3-(3-hexyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole,iodide; 3-hexyl-2-[3-(3-hexyl-2(3H)benzoxazolylidene)-1-propenyl]benzoxazolium iodide
Molecular FormulaC29H37IN2O2
Molecular Weight572.52
Purity98%
Melting Point219-221 °C (lit.)
Appearancepowder or chunks
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53213-82-4 |
| Catalog No. | 2A-9043922 |
| Chinese Name | 碘代3,3'-二己氧基羰花青 |
| Synonyms | MFCD00011954; DiOC6(3) [3,3'-Dihexyloxacarbocyanine iodide]; 3-hexyl-2-[3-(3-hexyl-1,3-benzoxazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzoxazole,iodide; 3-hexyl-2-[3-(3-hexyl-2(3H)benzoxazolylidene)-1-propenyl]benzoxazolium iodide |
| Molecular Formula | C29H37IN2O2 |
| Molecular Weight | 572.52 |
| Purity | 98 |
| Melting Point | 219-221 °C (lit.) |
| Appearance | powder or chunks |
| Storage Condition | Keep the container sealed and stored in a cool, dr |
| Application | 3,3'-Dihexyloxacarbocyanine iodide is a carbocyanine dye that can be used to detect changes in mitochondrial membrane potential. |
| PubChem ID | 24859130 |
| MDL Number | MFCD00011954 |
| SMILES | [I-].CCCCCCN1\C(Oc2ccccc12)=C\C=C\c3oc4ccccc4[n+]3CCCCCC |
| InChI | 1S/C29H37N2O2.HI/c1-3-5-7-13-22-30-24-16-9-11-18-26(24)32-28(30)20-15-21-29-31(23-14-8-6-4-2)25-17-10-12-19-27(25)33-29;/h9-12,15-21H,3-8,13-14,22-23H2,1-2H3;1H/q+1;/p-1 |
| InChI Key | XVLXYDXJEKLXHN-UHFFFAOYSA-M |
| Beilstein/REAXYS | 9312562 |
| NACRES Code | NA.47 |
| UNSPSC | 12171500 |
| Hazard Symbols | transportation |
| MSDS | msds/43922_1_53213_82_4.pdf |
| Bioactivity | 3,3'-Dihexyloxacarbocyanine iodide is a carbocyanine dye which can be used to monitor changes in mitochondrial membrane potential. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Dye Reagents In Vitro Addition of cells to the cuvette containing 0.25 μM 3,3'-Dihexyloxacarbocyanine iodide (DiOCg(3)) leads to an increase in fluorescence, equilibration is rapid and is complete by 4 min. When f-met-leu-phe (10-7 M) is added to neutrophils preequilibrated with 3,3'-Dihexyloxacarbocyanine iodide, there is a short lag period of 5 seconds. The lag period is followed by a rapid loss of fluorescence. Examination of 3,3'-Dihexyloxacarbocyanine iodide loaded neutrophils using fluorescence microscopy demonstrates that in resting neutrophils the brightest fluorescence is associated with long thin organelles which corresponds to the distribution of mitochondria[1]. Cell Assay Neutrophils (2.5×106/mL) are preequilibrated in 0.25 μM 3,3'-Dihexyloxacarbocyanine iodide (DiOCg(3)) for 5 min at 37°C in a 1 cm path length cuvette. Final volume is 2 mL. Fluorescence measurements are made in a spectrofluorimeter (emission wavelength: 510 nm, excitation wavelength: 470 nm). Stimuli are injected by a syringe through an injection port on the spectrofluorimeter, and their volumes never exceed 5% (v/v)[1]. References [1]. Korchak HM, et al. A carbocyanine dye, DiOC6(3), acts as a mitochondrial probe in human neutrophils. Biochem Biophys Res Commun. 1982 Oct 29;108(4):1495-501. Chemical & Physical Properties Melting Point 219-221 °C(lit.) Molecular Formula C29H37IN2O2 Molecular Weight 572.52100 Exact Mass 572.19000 PSA 35.09000 LogP 4.20760 InChIKey XVLXYDXJEKLXHN-UHFFFAOYSA-M SMILES CCCCCCN1C(=CC=Cc2oc3ccccc3[n+]2CCCCCC)Oc2ccccc21.[I-] |
| Use of | 3,3'-Dihexyloxacarbocyanine iodide is a carbocyanine dye which can be used to monitor changes in mitochondrial membrane potential. Properties Articles45 Name 3,3'-dihexyloxacarbocyanine iodide Synonym More Synonyms 3,3'-Dihexyloxacarbocyanine iodide Biological Activity Description 3,3'-Dihexyloxacarbocyanine iodide is a carbocyanine dye which can be used to monitor changes in mitochondrial membrane potential. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Dye Reagents References [1]. Korchak HM, et al. A carbocyanine dye, DiOC6(3), acts as a mitochondrial probe in human neutrophils. Biochem Biophys Res Commun. 1982 Oct 29;108(4):1495-501. Chemical & Physical Properties Molecular Formula C29H37IN2O2 Exact Mass 572.19000 PSA 35.09000 LogP 4.20760 InChIKey XVLXYDXJEKLXHN-UHFFFAOYSA-M |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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