CAS Number53177-12-1
Synonymseuk-8; 1,2-bis(salicylideneamino)ethane manganese(III) chloride; 2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate; Mn(salen)Cl; chloro-[N,N'-bis(salicylidene)ethylenediaminato]manganese(III); N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II); [manganese(III)Cl(N,N'-bis(salicylidene) ethylenediamine)]; Manganese(3+) chloride 2,2'-{1,2-ethanediylbis[nitrilo(E)methylylidene]}diphenolate (1:1:1); [2,2'-[ethane-1,2-diil-bis(nitrilo-methylidyne)]diphenolato]-manganese(III)-chloride; N,N'-Bis(salicylideneamino)ethane-manganese(II); (N,N'-ethylenebis(salicylideneaminato))MnCl; Salen-manganese complex
Molecular FormulaC16H14ClMnN2O2
Molecular Weight356.69
Purity98.00%
Boiling Point448.8ºC at 760mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53177-12-1 |
| Catalog No. | 2A-9043914 |
| Chinese Name | N,N'-双(亚水杨基)-1,2-乙二胺氯化-锰(III) |
| Synonyms | euk-8; 1,2-bis(salicylideneamino)ethane manganese(III) chloride; 2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate; Mn(salen)Cl; chloro-[N,N'-bis(salicylidene)ethylenediaminato]manganese(III); N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II); [manganese(III)Cl(N,N'-bis(salicylidene) ethylenediamine)]; Manganese(3+) chloride 2,2'-{1,2-ethanediylbis[nitrilo(E)methylylidene]}diphenolate (1:1:1); [2,2'-[ethane-1,2-diil-bis(nitrilo-methylidyne)]diphenolato]-manganese(III)-chloride; N,N'-Bis(salicylideneamino)ethane-manganese(II); (N,N'-ethylenebis(salicylideneaminato))MnCl; Salen-manganese complex |
| Molecular Formula | C16H14ClMnN2O2 |
| Molecular Weight | 356.69 |
| Purity | 98.00 |
| Boiling Point | 448.8ºC at 760mmHg |
| Storage Condition | -20°C |
| Application | Manganese chloride (salen) is a mimic of superoxide dismutase and catalase, and is an antioxidant with the property of scavenging oxygen free radicals. Manganese chloride (salen) improves acute lung i |
| PubChem ID | 14778836 |
| SMILES | [Cl-].[Mn+3].[O-]c1ccccc1C=NCCN=Cc1ccccc1[O-] |
| InChI | InChI=1S/C16H16N2O2.ClH.Mn/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;;/h1-8,11-12,19-20H,9-10H2;1H;/q;;+3/p-3 |
| InChI Key | HBQGFROGWOHBAG-UHFFFAOYSA-K |
| Hazard Symbols | transportation |
| Bioactivity | Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others In Vitro Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2]. In Vivo Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3]. Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3] Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis. References [1]. Gonzalez PK, et, al. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov;275(2):798-806. [2]. Bruce AJ, et, al. beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2312-6. [3]. Empel VPM, et, al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006 Aug 15;48(4):824-32. Chemical & Physical Properties Boiling Point 448.8ºC at 760mmHg Molecular Formula C16H14ClMnN2O2 Molecular Weight 356.686 Flash Point 294.1ºC Exact Mass 356.012421 PSA 70.84000 LogP 0.51620 InChIKey HBQGFROGWOHBAG-UHFFFAOYSA-K SMILES [Cl-].[Mn+3].[O-]c1ccccc1C=NCCN=Cc1ccccc1[O-] Storage condition -20°C |
| Use of | Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2]. Properties Articles22 Name manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride Synonym More Synonyms Biological Activity Description Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others In Vitro Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2]. References [1]. Gonzalez PK, et, al. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov;275(2):798-806. [2]. Bruce AJ, et, al. beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2312-6. [3]. Empel VPM, et, al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006 Aug 15;48(4):824-32. Chemical & Physical Properties Exact Mass 356.012421 PSA 70.84000 LogP 0.51620 InChIKey HBQGFROGWOHBAG-UHFFFAOYSA-K |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: - International Maritime Transport Danger Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Danger Regulations: - International Maritime Transport Danger Regulations: - 14.4 Package group European Land Transport Danger Regulations: - International Maritime Transport Danger Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Transport Danger Regulations Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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