CAS Number51898-34-1
SynonymsMFCD00057302; Vitamin E nicotinate; UNII:QCP2FMP7I8; EINECS 257-501-4; (2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl nicotinate
Molecular FormulaC35H53NO3
Molecular Weight535.80
Purity≥98%
Density1.0±0.1 g/cm3
Boiling Point649.0±55.0 °C at 760 mmHg
Appearancesolid or liquid
EINECS257-501-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 51898-34-1 |
| Catalog No. | 2A-9043621 |
| Chinese Name | (±)-α-烟酸生育酚 |
| Synonyms | MFCD00057302; Vitamin E nicotinate; UNII:QCP2FMP7I8; EINECS 257-501-4; (2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl nicotinate |
| Molecular Formula | C35H53NO3 |
| Molecular Weight | 535.80 |
| Purity | ≥98 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 649.0±55.0 °C at 760 mmHg |
| Appearance | solid or liquid |
| Storage Condition | Sealed, store at 2 ºC -8 ºC |
| Application | (±)-alpha-tocopheryl nicotinate, vitamin E-nicotinate is an orally active fat-soluble antioxidant that can prevent cell membrane lipid peroxidation. (±)-α-Tocopherol nicotinate is hydrolyzed into α-to |
| EINECS | 257-501-4 |
| PubChem ID | 24900260 |
| MDL Number | MFCD03548047 |
| SMILES | CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)c3cccnc3)c(C)c(C)c2O1 |
| InChI | 1S/C35H53NO3/c1-24(2)13-9-14-25(3)15-10-16-26(4)17-11-20-35(8)21-19-31-29(7)32(27(5)28(6)33(31)39-35)38-34(37)30-18-12-22-36-23-30/h12,18,22-26H,9-11,13-17,19-21H2,1-8H3/t25-,26-,35-/m1/s1 |
| InChI Key | MSCCTZZBYHQMQJ-AZAGJHQNSA-N |
| NACRES Code | NA.79 |
| UNSPSC | 12352211 |
| Hazard Symbols | transportation |
| MSDS | msds/43621_1_51898_34_1.pdf |
| Bioactivity | (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2]. Related Catalog Research Areas >> Cardiovascular Disease In Vitro (±)-α-Tocopherol nicotinate can help slow the progression of microangiopathy in type 2 diabetics by reducing lipid peroxidation stress in the red blood cell membrane, improving blood rheology and red blood cell deformability[1]. (±)-α-Tocopherol nicotinate (Vitamin E) (2 μg/mL, 24 h) increases the proportion of CD4+CD8-T cells in thymocytes by pretreating the thymic epithelial cell line IT45-R1 and then incubating it with immature T cells[2]. In Vivo (±)-α-Tocopherol nicotinate (Vitamin E) (in animal feedings, 50 mg/kg or 585 mg/kg, 7 weeks) significantly increases the proportion of CD4+CD8- T cells and the expression of ICAM-1 in thymic epithelial cells (TECs) isolated of male Fisher rats at high dose concentrations of 585 mg/kg compared to low dose treatment of 50 mg/kg[2]. References [1]. T W Chung, et al. Reducing lipid peroxidation stress of erythrocyte membrane by alpha-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabet Med. 1998 May;15(5):380-5. [2]. Satoru Moriguchi, et al.Vitamin E enhances T cell differentiation through increased epithelial cell function in rat thymus,Nutrition Research,Volume 17, Issue 5,1997,Pages 873-883. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 649.0±55.0 °C at 760 mmHg Molecular Formula C35H53NO3 Molecular Weight 535.800 Flash Point 346.3±31.5 °C Exact Mass 535.402527 PSA 48.42000 LogP 13.23 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.514 InChIKey MSCCTZZBYHQMQJ-AZAGJHQNSA-N SMILES Cc1c(C)c2c(c(C)c1OC(=O)c1cccnc1)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2 Storage condition 2-8°C |
| Use of | (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2]. Properties Articles25 Name (±)-α-Tocopherol nicotinate Synonym More Synonyms Vitamin E Nicotinate Biological Activity Description (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2]. Related Catalog Research Areas >> Cardiovascular Disease In Vitro (±)-α-Tocopherol nicotinate can help slow the progression of microangiopathy in type 2 diabetics by reducing lipid peroxidation stress in the red blood cell membrane, improving blood rheology and red blood cell deformability[1]. (±)-α-Tocopherol nicotinate (Vitamin E) (2 μg/mL, 24 h) increases the proportion of CD4+CD8-T cells in thymocytes by pretreating the thymic epithelial cell line IT45-R1 and then incubating it with immature T cells[2]. References [1]. T W Chung, et al. Reducing lipid peroxidation stress of erythrocyte membrane by alpha-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabet Med. 1998 May;15(5):380-5. [2]. Satoru Moriguchi, et al.Vitamin E enhances T cell differentiation through increased epithelial cell function in rat thymus,Nutrition Research,Volume 17, Issue 5,1997,Pages 873-883. Chemical & Physical Properties Molecular Formula C35H53NO3 Exact Mass 535.402527 PSA 48.42000 LogP 13.23 Index of Refraction 1.514 InChIKey MSCCTZZBYHQMQJ-AZAGJHQNSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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