CAS Number51022-70-9
SynonymsAnebron; Salbutamol (hemisulfate); Loftan; (RS)-4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol hemisulfate; Volma; (RS)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]-2-(tert-butylamino)ethanol sulfate (2:1); albuterol hemisulfate; MFCD00148978; Salbutamol sulfate; Almotex; EINECS 242-424-0; Mozal; Respax; Ecovent; Asmaven; Asmadil; Cetsim
Molecular FormulaC13H22NO5S0.5
Molecular Weight272.35
Purity98.00%
Boiling Point419.2ºC at 760 mmHg
Melting Point180 °C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 51022-70-9 |
| Catalog No. | 2A-9043393 |
| Chinese Name | 硫酸沙丁胺醇 |
| Synonyms | Anebron; Salbutamol (hemisulfate); Loftan; (RS)-4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol hemisulfate; Volma; (RS)-1-[4-hydroxy-3-(hydroxymethyl)phenyl]-2-(tert-butylamino)ethanol sulfate (2:1); albuterol hemisulfate; MFCD00148978; Salbutamol sulfate; Almotex; EINECS 242-424-0; Mozal; Respax; Ecovent; Asmaven; Asmadil; Cetsim |
| Molecular Formula | C13H22NO5S0.5 |
| Molecular Weight | 272.35 |
| Purity | 98.00 |
| Boiling Point | 419.2ºC at 760 mmHg |
| Melting Point | 180 °C |
| Appearance | powder |
| Storage Condition | Keep the container sealed and stored in a cool, dr |
| Application | Salbutamol Hemisulfate is a short-acting beta2-adrenoceptor agonist. |
| PubChem ID | 145044 |
| SMILES | CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.O=S(=O)(O)O |
| InChI | InChI=1S/C13H21NO3.H2O4S/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4) |
| InChI Key | BNPSSFBOAGDEEL-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/43393_1_51022_70_9.pdf |
| Bioactivity | Salbutamol Hemisulfate is a short-acting β2 adrenergic receptor agonistTarget: β2 Adrenergic ReceptorSalbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. All the effects of R,S-salbutamol on guinea-pig skeletal muscles are due to the activity of the R-enantiomer. Thus there is a common enantiomeric profile for the skeletal muscle and bronchorelaxant activity of the compound [1]. Short-term Salbutamol intake did appear to improve performance during intense submaximal exercise with concomitant increase in substrate availability and utilization, but the exact mechanisms involved need further investigation [2]. Short-term administration of salbutamol increases voluntary muscle strength in man. However, the magnitude and duration of this effect vary between muscle groups. This study implies that the beta 2-adrenoceptor agonists may be of therapeutic potential in altering skeletal muscle function in humans [3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology References [1]. Prior, C., M.B. Leonard, and J.R. McCullough, Effects of the enantiomers of R,S-salbutamol on incompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig. Br J Pharmacol, 1998. 123(3): p. 558-64. [2]. Collomp, K., et al., Effects of short-term oral salbutamol administration on exercise endurance and metabolism. J Appl Physiol (1985), 2000. 89(2): p. 430-6. [3]. Martineau, L., et al., Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men. Clin Sci (Lond), 1992. 83(5): p. 615-21. Chemical & Physical Properties Boiling Point 419.2ºC at 760 mmHg Melting Point 180 °C Molecular Formula C13H22NO5S0.5 Molecular Weight 288.14 Flash Point 250 °C PSA 155.70000 LogP 2.12490 InChIKey BNPSSFBOAGDEEL-UHFFFAOYSA-N SMILES CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.O=S(=O)(O)O Storage condition Store at RT |
| Use of | Salbutamol Hemisulfate is a short-acting β2 adrenergic receptor agonistTarget: β2 Adrenergic ReceptorSalbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. All the effects of R,S-salbutamol on guinea-pig skeletal muscles are due to the activity of the R-enantiomer. Thus there is a common enantiomeric profile for the skeletal muscle and bronchorelaxant activity of the compound [1]. Short-term Salbutamol intake did appear to improve performance during intense submaximal exercise with concomitant increase in substrate availability and utilization, but the exact mechanisms involved need further investigation [2]. Short-term administration of salbutamol increases voluntary muscle strength in man. However, the magnitude and duration of this effect vary between muscle groups. This study implies that the beta 2-adrenoceptor agonists may be of therapeutic potential in altering skeletal muscle function in humans [3]. Properties Articles95 Name Albuterol sulfate Synonym More Synonyms Albuterol sulfate Biological Activity Description Salbutamol Hemisulfate is a short-acting β2 adrenergic receptor agonistTarget: β2 Adrenergic ReceptorSalbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. All the effects of R,S-salbutamol on guinea-pig skeletal muscles are due to the activity of the R-enantiomer. Thus there is a common enantiomeric profile for the skeletal muscle and bronchorelaxant activity of the compound [1]. Short-term Salbutamol intake did appear to improve performance during intense submaximal exercise with concomitant increase in substrate availability and utilization, but the exact mechanisms involved need further investigation [2]. Short-term administration of salbutamol increases voluntary muscle strength in man. However, the magnitude and duration of this effect vary between muscle groups. This study implies that the beta 2-adrenoceptor agonists may be of therapeutic potential in altering skeletal muscle function in humans [3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology References [1]. Prior, C., M.B. Leonard, and J.R. McCullough, Effects of the enantiomers of R,S-salbutamol on incompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig. Br J Pharmacol, 1998. 123(3): p. 558-64. [2]. Collomp, K., et al., Effects of short-term oral salbutamol administration on exercise endurance and metabolism. J Appl Physiol (1985), 2000. 89(2): p. 430-6. [3]. Martineau, L., et al., Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men. Clin Sci (Lond), 1992. 83(5): p. 615-21. Chemical & Physical Properties Molecular Formula C13H22NO5S0.5 PSA 155.70000 LogP 2.12490 InChIKey BNPSSFBOAGDEEL-UHFFFAOYSA-N Storage condition Store at RT |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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