CAS Number50293-90-8
SynonymsMFCD08067728; (R)-Albuterol hydrochloride; levosalbutamol hydrochloride; Levalbuterol Hydrochloride; (-)-a1-(((1,1-Dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedimethanol Hydrochloride; 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol hydrochloride; 1,3-benzenedimethanol, α-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (αR)-, hydrochloride; 1,3-Benzenedimethanol, α-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (αR)-, hydrochloride (1:1); (R)-Salbutamol hydrochloride; 2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}phenol hydrochloride (1:1); Levalbuterol HCl; (-)-Salbutamol hydrochloride; (r)-(-)-a1-((tert-butylamino)methyl)-4-hydroxy-m-xylene-a,a'-diol hydrochloride; 2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}ph
Molecular FormulaC13H22ClNO3
Molecular Weight289.80
Purity98.00%
Boiling Point433.5ºC at 760 mmHg
Melting Point169-171ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50293-90-8 |
| Catalog No. | 2A-9043229 |
| Chinese Name | 盐酸左旋沙丁胺醇 |
| Synonyms | MFCD08067728; (R)-Albuterol hydrochloride; levosalbutamol hydrochloride; Levalbuterol Hydrochloride; (-)-a1-(((1,1-Dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedimethanol Hydrochloride; 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol hydrochloride; 1,3-benzenedimethanol, α-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (αR)-, hydrochloride; 1,3-Benzenedimethanol, α-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (αR)-, hydrochloride (1:1); (R)-Salbutamol hydrochloride; 2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}phenol hydrochloride (1:1); Levalbuterol HCl; (-)-Salbutamol hydrochloride; (r)-(-)-a1-((tert-butylamino)methyl)-4-hydroxy-m-xylene-a,a'-diol hydrochloride; 2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}ph |
| Molecular Formula | C13H22ClNO3 |
| Molecular Weight | 289.80 |
| Purity | 98.00 |
| Boiling Point | 433.5ºC at 760 mmHg |
| Melting Point | 169-171ºC |
| Appearance | powder |
| Storage Condition | -20°C |
| Application | Levbuterol ((R)-albuterol) hydrochloride is a short-acting β2-adrenoceptor agonist and the active (R)-enantiomer of salbutamol. Levbuterol hydrochloride is a more effective bronchodilator than albuter |
| PubChem ID | 7849340 |
| SMILES | CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.Cl |
| InChI | InChI=1S/C13H21NO3.ClH/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;/h4-6,12,14-17H,7-8H2,1-3H3;1H/t12-;/m0./s1 |
| InChI Key | OWNWYCOLFIFTLK-YDALLXLXSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/43229_1_50293_90_8.pdf |
| Bioactivity | Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology In Vitro Levalbuterol (10 μM; 24 hours) hydrochloride induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression in airway epithelial cells[1]. Levalbuterol (10 μM; 24 hours) hydrochloride significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1]. RT-PCR[1] Cell Line: Murine Club (MTCC) cells Concentration: 10 μM Incubation Time: 24 hours Result: Increased 11β-HSD1 mRNA expression selectively. In Vivo Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) hydrochloride significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[2]. Animal Model: C57BL/6 female mice with a pulmonary allergic model[2] Dosage: 1 mg/kg Administration: Subcutaneous injection; 1 mg/kg; 14 days Result: Decreased pulmonary inflammation after OVA sensitization. References [1]. Randall MJ, et, al. Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells. Front Endocrinol (Lausanne). 2015 Jan 12;5:236. [2]. Ferrada MA, et, al. (R)-albuterol decreases immune responses: role of activated T cells. Respir Res. 2008 Jan 14;9(1):3. Chemical & Physical Properties Boiling Point 433.5ºC at 760 mmHg Melting Point 169-171ºC Molecular Formula C13H22ClNO3 Molecular Weight 275.772 Exact Mass 275.128815 PSA 72.72000 LogP 2.49890 InChIKey OWNWYCOLFIFTLK-YDALLXLXSA-N SMILES CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.Cl Storage condition -20°C |
| Use of | Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1]. Properties Name 2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino ]ethyl}phenol hydrochloride (1:1) Synonym More Synonyms Levalbuterol Hydrochloride Biological Activity Description Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology References [1]. Randall MJ, et, al. Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells. Front Endocrinol (Lausanne). 2015 Jan 12;5:236. [2]. Ferrada MA, et, al. (R)-albuterol decreases immune responses: role of activated T cells. Respir Res. 2008 Jan 14;9(1):3. Chemical & Physical Properties Exact Mass 275.128815 PSA 72.72000 LogP 2.49890 InChIKey OWNWYCOLFIFTLK-YDALLXLXSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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