CAS Number42373-41-1
SynonymsAdenosintriphosphat,Tetrakaliumsalz; 5'-ATP-K2; ADENOSINE-5'-TRIPHOSPHATE DIPOTASSIUM SALT; Adenosine 5'-(tetrahydrogen triphosphate),dipotassiuM salt; adenosine 5'-triphosphate dipotassium*from bacter; MFCD00084672; ADENOSINE 5'-TRIPHOSPHATE DIPOTASSIUMFRO M BACTERIA; ATP POTASSIUM SALT
Molecular FormulaC10H14K2N5O13P3
Molecular Weight583.36 (anhydrous basis)
Purity≥92 (HPLC)%
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 42373-41-1 |
| Catalog No. | 2A-9042955 |
| Chinese Name | 腺苷5'-三磷酸二钾盐 |
| Synonyms | Adenosintriphosphat,Tetrakaliumsalz; 5'-ATP-K2; ADENOSINE-5'-TRIPHOSPHATE DIPOTASSIUM SALT; Adenosine 5'-(tetrahydrogen triphosphate),dipotassiuM salt; adenosine 5'-triphosphate dipotassium*from bacter; MFCD00084672; ADENOSINE 5'-TRIPHOSPHATE DIPOTASSIUMFRO M BACTERIA; ATP POTASSIUM SALT |
| Molecular Formula | C10H14K2N5O13P3 |
| Molecular Weight | 583.36 (anhydrous basis) |
| Purity | ≥92 (HPLC) |
| Appearance | powder |
| Storage Condition | Sealed, cool and dry storage |
| Application | ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is an important substance for energy storage and metabolism in the body, providing energy for metabolism and functioning as a coenzyme in cells. |
| PubChem ID | 24891383 |
| MDL Number | MFCD00084672 |
| SMILES | [K+].[K+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O |
| InChI | 1S/C10H16N5O13P3.2K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1 |
| InChI Key | YFPSRAQDZYNYPX-IDIVVRGQSA-L |
| NACRES Code | NA.51 |
| eCl@ss | 32160414 |
| UNSPSC | 41106305 |
| Hazard Symbols | transportation |
| MSDS | msds/42955_1_42373_41_1.pdf |
| Bioactivity | ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease In Vitro ATP dipotassium (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4]. ATP dipotassium stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4]. In Vivo ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP dipotassium induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4] Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial (E. coli) challenge Result: Protected mice from bacterial infection. References [1]. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. Chemical & Physical Properties Molecular Formula C10H14K2N5O13P3 Molecular Weight 583.36200 Exact Mass 582.90800 PSA 314.22000 InChIKey YFPSRAQDZYNYPX-UHFFFAOYSA-L SMILES Nc1ncnc2c1ncn2C1OC(COP(=O)(O)OP(=O)(O)OP(=O)([O-])[O-])C(O)C1O.[K+].[K+] |
| Use of | ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation[1][2]. Properties Name adenosine 5'-triphosphate potassium salt Synonym More Synonyms ATP dipotassium Biological Activity Description ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease References [1]. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. Chemical & Physical Properties Molecular Formula C10H14K2N5O13P3 Exact Mass 582.90800 PSA 314.22000 InChIKey YFPSRAQDZYNYPX-UHFFFAOYSA-L |
| Transport Info | Product name: Purity: 92.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
| Related Products in Biotechnology & Diagnostics | ||
|---|---|---|
| Guanosine 3',5'-cyclic monophosphate sodium salt | 40732-48-7 | 2A-9042639 |
| 2-(Boc-aminomethyl)phenylacetic acid | 40851-66-9 | 2A-9042664 |
| N-Boc-L-Homoserine | 41088-86-2 | 2A-9042721 |
| S-Boc-2-mercapto-4,6-dimethylpyrimidine | 41840-28-2 | 2A-9042870 |
| 2'-Deoxyuridine 5'-monophosphate disodium salt | 42155-08-8 | 2A-9042914 |
| 2',3'-Dideoxy-2',3'-didehydroinosine | 42867-68-5 | 2A-9043029 |
| Nicotinamide hypoxanthine dinucleotide phosphate reduced tetrasodium salt | 42934-87-2 | 2A-9043050 |
| Guanosine 5'-diphosphate sodium salt | 43139-22-6 | 2A-9043082 |
| Boc-L-citrulline | 45234-13-7 | 2A-9043111 |
| Boc-O-methyl-L-threonine | 48068-25-3 | 2A-9043166 |
| Browse all Biotechnology & Diagnostics products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS