CAS Number41100-52-1
Synonyms1,3-Dimethyl-5-aminoadamantane hydrochloride; Axura; 3,5-Dimethyl-1-adamantanamine Hydrochloride; 3,5-Dimethyladamantan-1-amine hydrochloride (1:1); MFCD00214336; 3,5-Dimethyltricyclo[3.3.1.1]decan-1-aminhydrochlorid; Ebixza; 1-Amino-3,5-dimethyladamantane Hydrochloride; Tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride (1:1); 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride; Memantine Hydrochloride; 3,5-diméthyltricyclo[3.3.1.1]décan-1-amine chlorhydrate; Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride; Ebixia; SUN Y7017; 3,5-Dimethyl-1-adamantanamine hydrochloride (1:1); EINECS 255-219-6; tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride; 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride (1:1); MemantineHCl; 3,5-Dimethyladamantan-1-a
Molecular FormulaC12H22ClN
Molecular Weight215.76
Purity99.00%
Boiling Point239.8ºC at 760 mmHg
Melting Point292 °C
Appearancecrystalline solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 41100-52-1 |
| Catalog No. | 2A-9042724 |
| Chinese Name | 盐酸美金刚 |
| Synonyms | 1,3-Dimethyl-5-aminoadamantane hydrochloride; Axura; 3,5-Dimethyl-1-adamantanamine Hydrochloride; 3,5-Dimethyladamantan-1-amine hydrochloride (1:1); MFCD00214336; 3,5-Dimethyltricyclo[3.3.1.1]decan-1-aminhydrochlorid; Ebixza; 1-Amino-3,5-dimethyladamantane Hydrochloride; Tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride (1:1); 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride; Memantine Hydrochloride; 3,5-diméthyltricyclo[3.3.1.1]décan-1-amine chlorhydrate; Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride; Ebixia; SUN Y7017; 3,5-Dimethyl-1-adamantanamine hydrochloride (1:1); EINECS 255-219-6; tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride; 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride (1:1); MemantineHCl; 3,5-Dimethyladamantan-1-a |
| Molecular Formula | C12H22ClN |
| Molecular Weight | 215.76 |
| Purity | 99.00 |
| Boiling Point | 239.8ºC at 760 mmHg |
| Melting Point | 292 °C |
| Appearance | crystalline solid |
| Water Solubility | Water solubility: soluble |
| Storage Condition | Sealed, cool and dry storage |
| Application | Memantine is an amantadine derivative with weak to moderate affinity for NMDA receptors and can inhibit CYP2B6 and YP2D6. |
| HTC | 2921300090 |
| PubChem ID | 329750349 |
| SMILES | CC12CC3CC(C)(C1)CC(N)(C3)C2.Cl |
| InChI | InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H |
| InChI Key | LDDHMLJTFXJGPI-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease References [1]. Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66(11): p. 1515-34. [2]. Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36. [3]. Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46. Chemical & Physical Properties Boiling Point 239.8ºC at 760 mmHg Melting Point 292 °C Molecular Formula C12H22ClN Molecular Weight 215.763 Flash Point 92.3ºC Exact Mass 215.144073 PSA 26.02000 LogP 4.19640 InChIKey LDDHMLJTFXJGPI-UHFFFAOYSA-N SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2.Cl Storage condition -20°C Freezer |
| Use of | Properties Articles14 Name memantine hydrochloride Synonym More Synonyms memantine hydrochloride Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease References [1]. Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66(11): p. 1515-34. [2]. Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36. [3]. Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46. Chemical & Physical Properties Exact Mass 215.144073 PSA 26.02000 LogP 4.19640 InChIKey LDDHMLJTFXJGPI-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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