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Carbidopa structure, CAS 38821-49-7

Carbidopa

CAS Number38821-49-7

SynonymsBenzenepropanoic acid, α-hydrazinyl-3,4-dihydroxy-α-methyl-, (αS)-, hydrate (1:1); CARBIDOPA 1-HYDRATE,PHARMA; Carbidopa; (S)-Carbidopa; 1-a-(3,4-Dihydroxybenzyl)-a-hydrazinopropionic Acid; L-a-Methyldopahydrazine; (aS)-a-Hydrazino-3,4-dihydroxy-a-methylbenzenepropanoic Acid; CARBIDOPA MONOHYDRATE; (S)-(-)-CARBIDOPA MONOHYDRATE; a-Methyldopahydrazine; Lodosin; carbidopa [INN_en]; CARBIDOPA HYDRATE; CARBIDOPA(GMP CERTIFICATE); (S)-(-)-Carbidopa; HMD; CARBIDOPA,USP; (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid hydrate (1:1); (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid; S-(−)-Carbidopa; (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate; CARBIDOPA 1-HYDRATE; (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate

Molecular FormulaC10H14O4N2

Molecular Weight226.23

Purity98.00%

Density1.42 g/cm3

Boiling Point528.7ºC at 760 mmHg

Melting Point

Flash Point

Appearance

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Cat. No.: 2A-9042210 Purity: 98.00%
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Quality Control of [ 38821-49-7 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number38821-49-7
Catalog No.2A-9042210
Chinese Name卡比多巴
SynonymsBenzenepropanoic acid, α-hydrazinyl-3,4-dihydroxy-α-methyl-, (αS)-, hydrate (1:1); CARBIDOPA 1-HYDRATE,PHARMA; Carbidopa; (S)-Carbidopa; 1-a-(3,4-Dihydroxybenzyl)-a-hydrazinopropionic Acid; L-a-Methyldopahydrazine; (aS)-a-Hydrazino-3,4-dihydroxy-a-methylbenzenepropanoic Acid; CARBIDOPA MONOHYDRATE; (S)-(-)-CARBIDOPA MONOHYDRATE; a-Methyldopahydrazine; Lodosin; carbidopa [INN_en]; CARBIDOPA HYDRATE; CARBIDOPA(GMP CERTIFICATE); (S)-(-)-Carbidopa; HMD; CARBIDOPA,USP; (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid hydrate (1:1); (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid; S-(−)-Carbidopa; (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate; CARBIDOPA 1-HYDRATE; (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate
Molecular FormulaC10H14O4N2
Molecular Weight226.23
Purity98.00
Density1.42 g/cm3
Boiling Point528.7ºC at 760 mmHg
Storage ConditionWarehouse low temperature ventilation and drying
ApplicationCarbidopa ((S)-(-)-Carbidopa) monohydrate is a peripheral decarboxylase inhibitor that can be used in the study of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (
HTC2932999099
PubChem ID7847624
MDL NumberMFCD02114422
SMILESCC(Cc1ccc(O)c(O)c1)(NN)C(=O)O.O
InChIInChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1
InChI KeyQTAOMKOIBXZKND-PPHPATTJSA-N
MSDSmsds/42210_1_38821_49_7.pdf
BioactivityCarbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Neurological Disease In Vitro Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191[1]. Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC50=29 μM)[3]. In Vivo Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts[1]. References [1]. Safe S. Carbidopa: a selective Ah receptor modulator (SAhRM). Biochem J. 2017;474(22):3763-3765. Published 2017 Nov 6. [2]. Fermaglich J. Treatment of Parkinson's disease with carbidopa, a peripheral decarboxylase inhibitor, and levodopa. Med Ann Dist Columbia. 1974;43(12):587-591. [3]. Gilbert JA, et al. The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Clin Cancer Res. 2000;6(11):4365-4372. Chemical & Physical Properties Density 1.42 g/cm3 Boiling Point 528.7ºC at 760 mmHg Molecular Formula C10H16N2O5 Molecular Weight 244.244 Flash Point 273.5ºC Exact Mass 244.105927 PSA 125.04000 LogP 0.97380 InChIKey QTAOMKOIBXZKND-PPHPATTJSA-N SMILES CC(Cc1ccc(O)c(O)c1)(NN)C(=O)O.O
Use ofCarbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2]. Properties Articles48 Name carbidopa Synonym More Synonyms Carbidopa monohydrate Biological Activity Description Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Neurological Disease References [1]. Safe S. Carbidopa: a selective Ah receptor modulator (SAhRM). Biochem J. 2017;474(22):3763-3765. Published 2017 Nov 6. [2]. Fermaglich J. Treatment of Parkinson's disease with carbidopa, a peripheral decarboxylase inhibitor, and levodopa. Med Ann Dist Columbia. 1974;43(12):587-591. [3]. Gilbert JA, et al. The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Clin Cancer Res. 2000;6(11):4365-4372. Chemical & Physical Properties Molecular Formula C10H16N2O5 Exact Mass 244.105927 PSA 125.04000 LogP 0.97380 InChIKey QTAOMKOIBXZKND-PPHPATTJSA-N
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Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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