CAS Number39028-27-8
Synonyms1-(2-Iodoacetoxy)-2,5-pyrrolidinedione; N-SucciniMidyl Iodoacetate; N-(Iodoacetoxy)succinimide; 1-(2-Iodoacetoxy)pyrrolidine-2,5-dione; Iodoacetic Acid N-Succinimidyl Ester; (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate; N-Succinimidyl iodoacetate(SIA)
Molecular FormulaC6H6INO4
Molecular Weight283.02
Purity98.00%
Density2.1±0.1 g/cm3
Boiling Point315.6±44.0 °C at 760 mmHg
Melting Point148ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 39028-27-8 |
| Catalog No. | 2A-9042250 |
| Chinese Name | 碘乙酸 N-羟基琥珀酰亚胺酯 |
| Synonyms | 1-(2-Iodoacetoxy)-2,5-pyrrolidinedione; N-SucciniMidyl Iodoacetate; N-(Iodoacetoxy)succinimide; 1-(2-Iodoacetoxy)pyrrolidine-2,5-dione; Iodoacetic Acid N-Succinimidyl Ester; (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate; N-Succinimidyl iodoacetate(SIA) |
| Molecular Formula | C6H6INO4 |
| Molecular Weight | 283.02 |
| Purity | 98.00 |
| Density | 2.1±0.1 g/cm3 |
| Boiling Point | 315.6±44.0 °C at 760 mmHg |
| Melting Point | 148ºC |
| Appearance | powder |
| Water Solubility | DMF: 50 mg/mL |
| Storage Condition | −20°C |
| Application | SIA Crosslinker is a non-cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs). |
| HTC | 2925190090 |
| PubChem ID | 57654310 |
| MDL Number | MFCD00058451 |
| SMILES | O=C(N1OC(CI)=O)CCC1=O |
| InChI | 1S/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2 |
| InChI Key | VRDGQQTWSGDXCU-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352005 |
| Hazard Symbols | transportation |
| MSDS | msds/42250_1_39028_27_8.pdf |
| Bioactivity | SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. Chemical & Physical Properties Density 2.1±0.1 g/cm3 Boiling Point 315.6±44.0 °C at 760 mmHg Melting Point 148ºC Molecular Formula C6H6INO4 Molecular Weight 283.021 Flash Point 144.7±28.4 °C Exact Mass 282.934143 PSA 63.68000 LogP -0.76 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.615 InChIKey VRDGQQTWSGDXCU-UHFFFAOYSA-N SMILES O=C(CI)ON1C(=O)CCC1=O Storage condition −20°C Water Solubility DMF: 50 mg/mL |
| Use of | SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Properties Name iodoacetic acid n-hydroxysuccinimide ester Synonym More Synonyms SIA Crosslinker Biological Activity Description SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. Chemical & Physical Properties Molecular Formula C6H6INO4 Exact Mass 282.934143 PSA 63.68000 LogP -0.76 Index of Refraction 1.615 InChIKey VRDGQQTWSGDXCU-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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