CAS Number38609-97-1
Synonymscridanimod; (9,10-Dihydro-9-oxo-10-acridinyl)acetic acid; MFCD00157050; (9-Oxo-10(9H)-acridinyl)acetic acid; 9-Oxo-10(9H)-acridineacetic acid; (9-oxoacridin-10(9H)-yl)acetic acid; 10-(Carboxymethyl)-9(10H)-acridone; 2-(9-oxoacridin-10-yl)acetic acid; 9-Oxoacridine-10-acetic Acid; 10-(Carboxymethyl)-9(10H)acridone; (9,10-Dihydro-9-oxo-10-acridinyl)acetic acid (10-(Carboxymethyl)-9(10H)acridone
Molecular FormulaC15H11NO3
Molecular Weight253.25
Purity≥99.0 (T)%
Density1.4±0.1 g/cm3
Boiling Point486.6±34.0 °C at 760 mmHg
Melting Point~289 °C (dec.)
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 38609-97-1 |
| Catalog No. | 2A-9042174 |
| Chinese Name | 吖啶酮乙酸 |
| Synonyms | cridanimod; (9,10-Dihydro-9-oxo-10-acridinyl)acetic acid; MFCD00157050; (9-Oxo-10(9H)-acridinyl)acetic acid; 9-Oxo-10(9H)-acridineacetic acid; (9-oxoacridin-10(9H)-yl)acetic acid; 10-(Carboxymethyl)-9(10H)-acridone; 2-(9-oxoacridin-10-yl)acetic acid; 9-Oxoacridine-10-acetic Acid; 10-(Carboxymethyl)-9(10H)acridone; (9,10-Dihydro-9-oxo-10-acridinyl)acetic acid (10-(Carboxymethyl)-9(10H)acridone |
| Molecular Formula | C15H11NO3 |
| Molecular Weight | 253.25 |
| Purity | ≥99.0 (T) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 486.6±34.0 °C at 760 mmHg |
| Melting Point | ~289 °C (dec.) |
| Appearance | solid |
| Water Solubility | Soluble in: dimethylformamide |
| Storage Condition | Room temperature, dry, sealed |
| Application | Cridanimod is a small molecule immunomodulator and interferon inducer. Cridanimod is a potent progesterone receptor (PR) activator that significantly increases PR expression by inducing the expression |
| HTC | 2933990090 |
| PubChem ID | 329751585 |
| MDL Number | MFCD00157050 |
| SMILES | OC(=O)CN1c2ccccc2C(=O)c3ccccc13 |
| InChI | 1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18) |
| InChI Key | UOMKBIIXHQIERR-UHFFFAOYSA-N |
| Beilstein/REAXYS | 227508 |
| NACRES Code | NA.32 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| MSDS | msds/42174_1_38609_97_1.pdf |
| Bioactivity | Cridanimod is a small-molecule immunomodulator and interferon inducer[1]. Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression[2]. Related Catalog Signaling Pathways >> Others >> Progesterone Receptor Signaling Pathways >> Immunology/Inflammation >> IFNAR Research Areas >> Inflammation/Immunology Target PR, IFNα, IFNβ[1] In Vivo Cridanimod (IM; 1-6 mg; twice a week) has a significantly longer survival time. Cridanimod significant increases in IFNα and -β in cridanimod-treated mice in a dose-dependent manner[1]. Animal Model: Athymic mice with hec50co cells[1] Dosage: 1, 3, 6 mg Administration: IM; twice a week Result: Had a significantly longer survival time. References [1]. Xenetic Biosciences Announces FDA Acceptance of Investigational New Drug Application to Initiate Phase 2 Clinical Trial of Virexxa® in Endometrial Cancer. AUGUST 19, 2016 [2]. Matthew J. Carlson, et al. Cridanimod and progestin therapy in hormone-resistant endometrial cancer. Journal of Clinical Oncology, January 30, 2017. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 486.6±34.0 °C at 760 mmHg Melting Point -289ºC (dec.) Molecular Formula C15H11NO3 Molecular Weight 253.253 Flash Point 248.1±25.7 °C Exact Mass 253.073898 PSA 59.30000 LogP 2.03 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.657 InChIKey UOMKBIIXHQIERR-UHFFFAOYSA-N SMILES O=C(O)Cn1c2ccccc2c(=O)c2ccccc21 |
| Use of | Cridanimod is a small-molecule immunomodulator and interferon inducer[1]. Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression[2]. Properties Articles30 Name 9-Oxo-10(9H)-acridineacetic acid Synonym More Synonyms 2-(9-Oxoacridin-10(9H)-yl)acetic acid Biological Activity Description Cridanimod is a small-molecule immunomodulator and interferon inducer[1]. Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression[2]. Related Catalog Signaling Pathways >> Others >> Progesterone Receptor Signaling Pathways >> Immunology/Inflammation >> IFNAR Research Areas >> Inflammation/Immunology PR, IFNα, IFNβ[1] References [2]. Matthew J. Carlson, et al. Cridanimod and progestin therapy in hormone-resistant endometrial cancer. Journal of Clinical Oncology, January 30, 2017. Chemical & Physical Properties Molecular Formula C15H11NO3 Exact Mass 253.073898 PSA 59.30000 Index of Refraction 1.657 InChIKey UOMKBIIXHQIERR-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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