CAS Number23180-57-6
Synonymspaeoniflorine; Paeony root; Delmacinone; Paeonia moutan; peoniflorin; MFCD00869331; Paeonia lactiflora P,E,; Paeoniflorm; EINECS 245-476-2; PAEONIFLORIN(P); ,Peoniflorin; PACLITAXEL
Molecular FormulaC23H28O11
Molecular Weight480.46
Purity≥98 (HPLC)%
Density1.6±0.1 g/cm3
Boiling Point690.2±55.0 °C at 760 mmHg
Appearancepowder
EINECS245-476-2
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 23180-57-6 |
| Catalog No. | 2A-9039198 |
| Chinese Name | 芍药苷 |
| Synonyms | paeoniflorine; Paeony root; Delmacinone; Paeonia moutan; peoniflorin; MFCD00869331; Paeonia lactiflora P,E,; Paeoniflorm; EINECS 245-476-2; PAEONIFLORIN(P); ,Peoniflorin; PACLITAXEL |
| Molecular Formula | C23H28O11 |
| Molecular Weight | 480.46 |
| Purity | ≥98 (HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 690.2±55.0 °C at 760 mmHg |
| Appearance | powder |
| Application | Paeoniflorin is a natural product extracted from white peony root. |
| EINECS | 245-476-2 |
| HTC | 2932999099 |
| PubChem ID | 329819989 |
| MDL Number | MFCD00869331 |
| SMILES | C[C@@]12C[C@@]3(O)O[C@@H](O1)[C@]5(COC(=O)c4ccccc4)[C@H]3C[C@]25O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O |
| InChI | 1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1 |
| InChI Key | YKRGDOXKVOZESV-WRJNSLSBSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352201 |
| MSDS | msds/39198_1_23180_57_6.pdf |
| Bioactivity | Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.Target: OthersPaeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease(PD) [1]. Paeoniflorin, a compound found in white peony that inhibited the production of testosterone and promoted the activity of aromatase, which converts testosterone into estrogen [2]. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid-binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 microg/ mL (166.4 microM). To our knowledge, this is the first report on the induction of HSPs by herbal medicines [3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Neurological Disease Natural Products >> Terpenoids and Glycosides References [1]. Cao, B.Y., et al., Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway. J Ethnopharmacol, 2010. 131(1): p. 122-9. [2]. Takeuchi, T., et al., Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. Am J Chin Med, 1991. 19(1): p. 73-8. [3]. Yan, D., et al., Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones, 2004. 9(4): p. 378-89. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 690.2±55.0 °C at 760 mmHg Molecular Formula C23H28O11 Molecular Weight 480.462 Flash Point 238.4±25.0 °C Exact Mass 480.163147 PSA 164.37000 LogP -0.42 Vapour Pressure 0.0±2.3 mmHg at 25°C Index of Refraction 1.683 InChIKey YKRGDOXKVOZESV-WRJNSLSBSA-N SMILES CC12CC3(O)OC(O1)C1(COC(=O)c4ccccc4)C3CC21OC1OC(CO)C(O)C(O)C1O Storage condition room temp |
| Use of | Properties Articles34 Name Paeoniflorin Synonym More Synonyms Paeoniflorin Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Neurological Disease Natural Products >> Terpenoids and Glycosides References [2]. Takeuchi, T., et al., Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. Am J Chin Med, 1991. 19(1): p. 73-8. [3]. Yan, D., et al., Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones, 2004. 9(4): p. 378-89. Chemical & Physical Properties Molecular Formula C23H28O11 Exact Mass 480.163147 PSA 164.37000 LogP -0.42 Index of Refraction 1.683 InChIKey YKRGDOXKVOZESV-WRJNSLSBSA-N Storage condition room temp |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 96.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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