CAS Number22368-21-4
Synonyms5,7-Dihydroxy-3',4',6-trimethoxyflavone; Eupatilin; 5,7-dihydroxy-6,3',4'-trimethoxyflavone; 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one; Euptailin; 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
Molecular FormulaC18H16O7
Molecular Weight344.32
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point583.6±50.0 °C at 760 mmHg
Melting Point236 °C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 22368-21-4 |
| Catalog No. | 2A-9038975 |
| Chinese Name | 异泽兰黄素; 泽兰林素 |
| Synonyms | 5,7-Dihydroxy-3',4',6-trimethoxyflavone; Eupatilin; 5,7-dihydroxy-6,3',4'-trimethoxyflavone; 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one; Euptailin; 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one |
| Molecular Formula | C18H16O7 |
| Molecular Weight | 344.32 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 583.6±50.0 °C at 760 mmHg |
| Melting Point | 236 °C |
| Appearance | powder |
| Storage Condition | 0-10°C; store in inert gas; avoid moisture (hygros |
| Application | Eupatilin is a lipophilic flavonoid isolated from Artemisia plants. It is an agonist of PPARα and has anti-apoptotic, antioxidant and anti-inflammatory effects. |
| HTC | 2932999099 |
| PubChem ID | 329826018 |
| MDL Number | MFCD13194819 |
| SMILES | O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C31 |
| InChI | 1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3 |
| InChI Key | DRRWBCNQOKKKOL-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/38975_1_22368_21_4.pdf |
| Use of | Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities. Properties Name eupatilin Synonym More Synonyms Eupatilin Biological Activity Description Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease References [1]. Jung Y, et al. Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice. Biochem Biophys Res Commun. 2018 Feb 5;496(2):508-514. [2]. Jung Y, et al. Eupatilin with PPARα agonistic effects inhibits TNFα-induced MMP signaling in HaCaT cells. Biochem Biophys Res Commun. 2017 Nov 4;493(1):220-226. [3]. Du L, et al. Eupatilin prevents H2O2-induced oxidative stress and apoptosis in human retinal pigment epithelial cells. Biomed Pharmacother. 2017 Jan;85:136-140. Chemical & Physical Properties Molecular Formula C18H16O7 Exact Mass 344.089600 PSA 98.36000 Index of Refraction 1.627 InChIKey DRRWBCNQOKKKOL-UHFFFAOYSA-N Safety Information HS Code 2932999099 Synthetic Route Total: 1 Page 2-(3,4-dimethox... CAS#:40983-99-1 CAS#:22368-21-4 Literature: Dong a Pharmaceutical Co., Ltd. Patent: US6025387 A1, 2000 ; Precursor & DownStream Precursor 1 CAS#:40983-99-1 2-(3,4-dimethox... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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