CAS Number22161-81-5
Synonyms(2S)-2-(3-Benzoylphenyl)propanoic acid; (S)-3-Benzoyl-a-methylbenzeneacetic Acid; MFCD00673316; (+)-(S)-m-Benzoylhydratropic acid; (+)-3-Benzoylhydratropic acid; Keral; (S)-(+)-2-(3-Benzoylphenyl)propionic acid; (2S)-2-(3-Benzoylphenyl)propionic Acid
Molecular FormulaC6H5COC6H4CH(CH3)CO2H
Molecular Weight254.28
Purity99%
Density1.2±0.1 g/cm3
Boiling Point431.3±28.0 °C at 760 mmHg
Melting Point75-78 °C (lit.)
AppearanceWhite or nearly white, crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 22161-81-5 |
| Catalog No. | 2A-9038896 |
| Chinese Name | 右旋酮洛芬 |
| Synonyms | (2S)-2-(3-Benzoylphenyl)propanoic acid; (S)-3-Benzoyl-a-methylbenzeneacetic Acid; MFCD00673316; (+)-(S)-m-Benzoylhydratropic acid; (+)-3-Benzoylhydratropic acid; Keral; (S)-(+)-2-(3-Benzoylphenyl)propionic acid; (2S)-2-(3-Benzoylphenyl)propionic Acid |
| Molecular Formula | C6H5COC6H4CH(CH3)CO2H |
| Molecular Weight | 254.28 |
| Purity | 99 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 431.3±28.0 °C at 760 mmHg |
| Melting Point | 75-78 °C (lit.) |
| Appearance | White or nearly white, crystalline powder |
| Storage Condition | Sealed, protected from light, ventilated and dry p |
| Application | S-(+)-Ketoprofen is a potent inhibitor of COX-1 and COX-2 with IC50 values of 1.9 and 27 nM, respectively. |
| HTC | 2942000000 |
| PubChem ID | 24870770 |
| MDL Number | MFCD00673316 |
| SMILES | C[C@H](C(O)=O)c1cccc(c1)C(=O)c2ccccc2 |
| InChI | 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1 |
| InChI Key | DKYWVDODHFEZIM-NSHDSACASA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352115 |
| Hazard Symbols | 6.1 |
| MSDS | msds/38896_1_22161_81_5.pdf |
| Bioactivity | S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively. Related Catalog Research Areas >> Inflammation/Immunology Target COX-1:13 μM (IC50) COX-2:370 μM (IC50) In Vitro S-(+)-Ketoprofen (Compound 1) is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively[1]. References [1]. Palomer A, et al. Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity ofketoprofen analogues. J Med Chem. 2000 Jun 1;43(11):2280-4. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 431.3±28.0 °C at 760 mmHg Melting Point 75-78ºC(lit.) Molecular Formula C16H14O3 Molecular Weight 254.281 Flash Point 228.8±20.5 °C Exact Mass 254.094299 PSA 54.37000 LogP 2.81 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.592 InChIKey DKYWVDODHFEZIM-NSHDSACASA-N SMILES CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1 Storage condition -20°C Freezer |
| Use of | S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively. Properties Name dexketoprofen Synonym More Synonyms S-(+)-Ketoprofen Biological Activity Description S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively. Related Catalog Research Areas >> Inflammation/Immunology COX-1:13 μM (IC50) COX-2:370 μM (IC50) In Vitro S-(+)-Ketoprofen (Compound 1) is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively[1]. References [1]. Palomer A, et al. Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity ofketoprofen analogues. J Med Chem. 2000 Jun 1;43(11):2280-4. Chemical & Physical Properties Molecular Formula C16H14O3 Exact Mass 254.094299 PSA 54.37000 Index of Refraction 1.592 InChIKey DKYWVDODHFEZIM-NSHDSACASA-N |
| Transport Info | Product name: (S)-(+)-ketoprofen |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| 11a-Hydroxy-16,17a-epoxyprogesterone | 19427-36-2 | 2A-0202152 |
| Trazodone | 19794-93-5 | 2A-9038215 |
| Memantine | 19982-08-2 | 2A-9038275 |
| tert-Butylpenicillin sodium salt | 20520-33-6 | 2A-9038436 |
| Gliclazide | 21187-98-4 | 2A-9038625 |
| Tramadol hydrochloride | 22204-88-2 | 2A-9038908 |
| Miconazole | 22916-47-8 | 2A-9039106 |
| Estradiol bis[4-[bis(2-chloroethyl)amino]benzeneacetate] | 22966-79-6 | 2A-9039126 |
| 7-(2-Bromoethyl)theophylline | 23146-05-6 | 2A-9039190 |
| Cerivastatin sodium | 143201-11-0 | 2A-9039665 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS