CAS Number20537-88-6
SynonymsMFCD00233058; Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester); Amifostine; Apaetp; 2-(3-aminopropylamino)ethylsulfanylphosphonic acid; Ethyol; WR 2721; Sapep; dihydrogène thiophosphate de S-{2-[(3-aminopropyl)amino]éthyle}; S-{2-[(3-Aminopropyl)amino]ethyl}dihydrogen-thiophosphat; Aminopropylaminoethyl thiophosphate; S-{2-[(3-Aminopropyl)amino]ethyl} dihydrogen phosphorothioate; Ethiofos; Gammaphos
Molecular FormulaC5H15N2O3PS
Molecular Weight214.23
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point441.7±51.0 °C at 760 mmHg
Melting Point160-161ºC
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 20537-88-6 |
| Catalog No. | 2A-9038442 |
| Chinese Name | 氨磷汀 |
| Synonyms | MFCD00233058; Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester); Amifostine; Apaetp; 2-(3-aminopropylamino)ethylsulfanylphosphonic acid; Ethyol; WR 2721; Sapep; dihydrogène thiophosphate de S-{2-[(3-aminopropyl)amino]éthyle}; S-{2-[(3-Aminopropyl)amino]ethyl}dihydrogen-thiophosphat; Aminopropylaminoethyl thiophosphate; S-{2-[(3-Aminopropyl)amino]ethyl} dihydrogen phosphorothioate; Ethiofos; Gammaphos |
| Molecular Formula | C5H15N2O3PS |
| Molecular Weight | 214.23 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 441.7±51.0 °C at 760 mmHg |
| Melting Point | 160-161ºC |
| Appearance | white solid |
| Storage Condition | Warehouse ventilation and low temperature drying |
| Application | Amifostine is a broad-spectrum cytoprotective agent that can resist the damaging effects of ionizing radiation and chemotherapy drugs on DNA. |
| HTC | 2930909090 |
| MDL Number | C5H15N2O3PS |
| SMILES | NCCCNCCSP(=O)(O)O |
| InChI | InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10) |
| InChI Key | JKOQGQFVAUAYPM-UHFFFAOYSA-N |
| MSDS | msds/38442_1_20537_88_6.pdf |
| Use of | Amifostine is a broad-spectrum cytoprotection agent against the DNA damaging effects of ionizing radiation and chemotherapy drug. Properties Name amifostine Synonym More Synonyms Amifostine Biological Activity Description Amifostine is a broad-spectrum cytoprotection agent against the DNA damaging effects of ionizing radiation and chemotherapy drug. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer References [1]. Kouvaris, J.R., V.E. Kouloulias, and L.J. Vlahos, Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist, 2007. 12(6): p. 738-47. Chemical & Physical Properties Molecular Formula C5H15N2O3PS Exact Mass 214.054092 PSA 130.69000 LogP -1.68 Index of Refraction 1.555 InChIKey JKOQGQFVAUAYPM-UHFFFAOYSA-N SMILES NCCCNCCSP(=O)(O)O Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Phosphorothioic acid, S-(2-(3-aminopropylamino)ethyl) ester CAS REGISTRY NUMBER : 20537-88-6 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C5-H15-N2-O3-P-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in calcium TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Primate - monkey DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Primate - monkey DOSE/DURATION : TOXIC EFFECTS : Cardiac - pulse rate Vascular - BP lowering not characterized in autonomic section Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 17-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 17-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 17-22 day(s) after conception lactating female 7 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - body wall TYPE OF TEST : Micronucleus test MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : REFERENCE : CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 54,1080,1985 Safety Information Hazard Codes Xn:Harmful Risk Phrases R22 Safety Phrases S26-S36 WGK Germany 3 RTECS TE6491000 HS Code 2930909090 Synthetic Route Total: 1 Page N-(2-Bromoethyl... CAS#:23545-42-8 Amifostine CAS#:20537-88-6 Literature: Laduranty, Joelle; Lion, Claude; Mesnard, Daniele; Miginiac, Leone Bulletin des Societes Chimiques Belges, 1984 , vol. 93, # 10 p. 903 - 912 CAS#:23545-33-7 Amifostine CAS#:20537-88-6 Literature: Bulletin des Societes Chimiques Belges, , vol. 93, # 10 p. 903 - 912 CAS#:23545-38-2 Amifostine CAS#:20537-88-6 Literature: Bulletin des Societes Chimiques Belges, , vol. 93, # 10 p. 903 - 912 Precursor & DownStream Precursor 1 CAS#:23545-42-8 N-(2-Bromoethyl... DownStream 0 |
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