CAS Number19767-45-4
Synonymssodium mercaptoethanesulfonate; 2-Mercaptoethanesulfonic acid monosodium salt; Mesnum; 2-Mercaptoethanesulfonic Acid Sodium Salt; Uromitexan; 2-mercaptoethanesulphonic acid sodium salt; 2-Mercaptoethanesulfonic acid sodium salt,Coenzyme M sodium salt,HS-CoM Na; Sodium 2-mercaptoethanesulfonate; sodium 2-Mercapto-ethanesulfonate; Ethanesulfonic acid, 2-mercapto-, sodium salt (1:1); Sodium 2-sulfanylethanesulfonate; Ethanesulfonic acid, 2-mercapto-, monosodium salt; Mesnex; mesnaum; UNII-NR7O1405Q9; mistabron; MFCD00007535; MESNA; 2-Mercaptoethane sulfonate sodium; mucofluid; EINECS 243-285-9; 2-Mercaptoethanesulfonate, sodium; mitexan; coenzyme M sodium salt
Molecular FormulaHSCH2CH2SO3Na
Molecular Weight164.18
Purity≥98.0 (titration)%
Melting Point>240°C dec.
AppearanceWhite to off-white solid
EINECS243-285-9
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 19767-45-4 |
| Catalog No. | 2A-9038206 |
| Chinese Name | 美司那 |
| Synonyms | sodium mercaptoethanesulfonate; 2-Mercaptoethanesulfonic acid monosodium salt; Mesnum; 2-Mercaptoethanesulfonic Acid Sodium Salt; Uromitexan; 2-mercaptoethanesulphonic acid sodium salt; 2-Mercaptoethanesulfonic acid sodium salt,Coenzyme M sodium salt,HS-CoM Na; Sodium 2-mercaptoethanesulfonate; sodium 2-Mercapto-ethanesulfonate; Ethanesulfonic acid, 2-mercapto-, sodium salt (1:1); Sodium 2-sulfanylethanesulfonate; Ethanesulfonic acid, 2-mercapto-, monosodium salt; Mesnex; mesnaum; UNII-NR7O1405Q9; mistabron; MFCD00007535; MESNA; 2-Mercaptoethane sulfonate sodium; mucofluid; EINECS 243-285-9; 2-Mercaptoethanesulfonate, sodium; mitexan; coenzyme M sodium salt |
| Molecular Formula | HSCH2CH2SO3Na |
| Molecular Weight | 164.18 |
| Purity | ≥98.0 (titration) |
| Melting Point | >240°C dec. |
| Appearance | White to off-white solid |
| Water Solubility | Water solubility: soluble |
| Storage Condition | Store sealed and dry. Deteriorated after being sto |
| Application | 2-mercaptoethane sulfonate (Mesna) is a chemoprotective agent that can be used in cyclophosphamide-induced hemorrhagic cystitis. |
| EINECS | 243-285-9 |
| HTC | 2930909090 |
| PubChem ID | 329817882 |
| MDL Number | MFCD00007535 |
| SMILES | [Na+].[O-]S(=O)(=O)CCS |
| InChI | 1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1 |
| InChI Key | XOGTZOOQQBDUSI-UHFFFAOYSA-M |
| Beilstein/REAXYS | 3657828 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/38206_1_19767_45_4.pdf |
| Bioactivity | 2-mercaptoethane sulfonate (Mesna), is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide.IC50 Value: 182 mM (decreased superoxide anion production stimulated with PMA (tetradecanoylphorbol acetate) in PMN in-vitro); 70mM (inhibited H2O2 production) [3]Target: in vitro: MESNA had no effect on the qualitative and quantitative characteristics of the indicated processes in both the types of the doxorubicin sensitive cells. The combined use of doxorubicin and phosphamide or cyclophosphane the use of MESNA for lowering the urotoxic action of oxazophosphorines had no effect on the biological efficacy of doxorubicin [4].in vivo: AMH-positive follicles were significantly decreased after cisplatin administration, which was significantly reversed when mesna was co-administered with cisplatin. The end product of lipid peroxidation, malondialdehyde (MDA), was significantly increased, but the anti-oxidative enzymatic activity of superoxide dismutase (SOD) and glutathione (GSH) were significantly decreased in cisplatin groups when compared with NS group. In contrast, after co-administration of cisplatin with mesna, MDA was significantly decreased whereas the activity of SOD and the concentration of GSH were increased. Moreover, mesna did not decrease the anti-tumor property of cisplatin in HePG2 cell lines [2]. After head trauma, tissue malondialdehyde levels increased; these levels were significantly decreased by MESNA administration. Caspase-3 levels were increased after trauma, but no effect of MESNA was determined in caspase-3 activity [1].Clinical trial: Effects of Mesna on Homocysteine in Kidney Failure . Phase2 Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer References [1]. Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir (Wien). 2013 Jan;155(1):141-9; discussion 149. [2]. Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24(2):177-85. [3]. Gressier B; Cabanis A; Lebegue S; Antioxidant Activity of Mesna: Interest During Pulmonary Inflammatory Diseases. Pharm.Weekbl. Sci.Ed., 1992, 14, No. 5, Suppl. F, F48 [4]. Bogush TA, Smirnova GB, Chmutin EF, Effect of MESNA on intracellular accumulation of doxorubicin and its interaction with DNA. Antibiot Khimioter. 1994 Sep-Oct;39(9-10):30-5. Chemical & Physical Properties Melting Point >240°C dec. Molecular Formula C2H5NaO3S2 Molecular Weight 164.179 Exact Mass 163.957779 PSA 104.38000 LogP 0.54220 InChIKey XOGTZOOQQBDUSI-UHFFFAOYSA-M SMILES O=S(=O)([O-])CCS.[Na+] Storage condition -20?C Freezer, Under Inert Atmosphere Stability Stable. Incompatible with strong oxidizing agents. |
| Use of | Properties Articles35 Name Mesna Synonym More Synonyms MESNA Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer References [1]. Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir (Wien). 2013 Jan;155(1):141-9; discussion 149. [2]. Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24(2):177-85. [3]. Gressier B; Cabanis A; Lebegue S; Antioxidant Activity of Mesna: Interest During Pulmonary Inflammatory Diseases. Pharm.Weekbl. Sci.Ed., 1992, 14, No. 5, Suppl. F, F48 [4]. Bogush TA, Smirnova GB, Chmutin EF, Effect of MESNA on intracellular accumulation of doxorubicin and its interaction with DNA. Antibiot Khimioter. 1994 Sep-Oct;39(9-10):30-5. Chemical & Physical Properties Molecular Formula C2H5NaO3S2 Exact Mass 163.957779 PSA 104.38000 LogP 0.54220 InChIKey XOGTZOOQQBDUSI-UHFFFAOYSA-M SMILES O=S(=O)([O-])CCS.[Na+] Storage condition -20?C Freezer, Under Inert Atmosphere Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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