CAS Number19387-91-8
SynonymsBioshik; 1-[2-(Ethylsulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole; Trimonase; Fasigyn; Fasygin; TINDAMAX; UNII-033KF7V46H; 1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitro-1H-imidazole; MFCD00057217; Tinidazolum; Simplotan; Tinidazol; Tinidazole; Fasigin; Tricolam; 1-[2-(Ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole; Ethyl[2-(2-methyl-5-nitro-1-imidazoIyl)ethyl]sulfone; Symplotan; EINECS 243-014-4
Molecular FormulaC8H13N3O4S
Molecular Weight247.27
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point528.4±30.0 °C at 760 mmHg
Melting Point117-121 °C(lit.)
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 19387-91-8 |
| Catalog No. | 2A-9038093 |
| Chinese Name | 替硝唑 |
| Synonyms | Bioshik; 1-[2-(Ethylsulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole; Trimonase; Fasigyn; Fasygin; TINDAMAX; UNII-033KF7V46H; 1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitro-1H-imidazole; MFCD00057217; Tinidazolum; Simplotan; Tinidazol; Tinidazole; Fasigin; Tricolam; 1-[2-(Ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole; Ethyl[2-(2-methyl-5-nitro-1-imidazoIyl)ethyl]sulfone; Symplotan; EINECS 243-014-4 |
| Molecular Formula | C8H13N3O4S |
| Molecular Weight | 247.27 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 528.4±30.0 °C at 760 mmHg |
| Melting Point | 117-121 °C(lit.) |
| Appearance | solid |
| Water Solubility | Water solubility: insoluble; soluble in: acetone; |
| Storage Condition | Refrigerator |
| Application | Tinidazole has dual antiprotozoal and antibacterial effects. |
| HTC | 2933290090 |
| MDL Number | MFCD00057217 |
| SMILES | CCS(=O)(=O)CCn1c(C)ncc1[N+]([O-])=O |
| InChI | 1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3 |
| InChI Key | HJLSLZFTEKNLFI-UHFFFAOYSA-N |
| Beilstein/REAXYS | 618182 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/38093_1_19387_91_8.pdf |
| Bioactivity | Tinidazole is a synthesized imidazole derivative used in antiprotozoal treatment with antiamebic and antibacterial properties.Target: AntibacterialTinidazole is a 5-nitroimidazole active in vitro against a wide variety of anaerobic bacteria and protozoa. Tinidazole is an effective treatment against anaerobic microorganisms based on its pharmacokinetic characteristics (C(max) 51 microg/ml, t(1/2) 12.5 h) and its excellent in vitro activity. Its long half-life allows once a day regimens. Tinidazole is as effective as metronidazole in the treatment of infections caused by T. vaginalis, giardiasis and amebiasis and bacterial vaginosis, malaria, odontogenic infections, anaerobic bacterial infections (pelvic inflammatory disease, diabetic foot), surgical prophylaxis (abdominal and hysterectomy) and Helicobacter pylori eradication. Tinidazole has recently been resurrected and FDA approved for trichomoniasis and BV in the USA and is being restudied as an alternative to metronidazole for BV. In vitro antimicrobial activity and pharmacokinetics studies indicate that when compared directly with metronidazole, tinidazole has minor but possibly relevant antimicrobial as well as pharmacokinetic advantages. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Granizo JJ, et al. Tinidazole: a classical anaerobical drug with multiple potential uses nowadays. Rev Esp Quimioter. 2009 Jun;22(2):106-14. [2]. Nailor MD, et al. Tinidazole for bacterial vaginosis. Expert Rev Anti Infect Ther. 2007 Jun;5(3):343-8. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 528.4±30.0 °C at 760 mmHg Melting Point 117-121 °C(lit.) Molecular Formula C8H13N3O4S Molecular Weight 247.271 Flash Point 273.4±24.6 °C Exact Mass 247.062683 PSA 106.16000 LogP -0.27 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.599 Storage condition Refrigerator Stability Stable. Incompatible with strong oxidizing agents. |
| Use of | Properties Articles44 Name 1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole Synonym More Synonyms Tinidazole Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Granizo JJ, et al. Tinidazole: a classical anaerobical drug with multiple potential uses nowadays. Rev Esp Quimioter. 2009 Jun;22(2):106-14. [2]. Nailor MD, et al. Tinidazole for bacterial vaginosis. Expert Rev Anti Infect Ther. 2007 Jun;5(3):343-8. Chemical & Physical Properties Molecular Formula C8H13N3O4S Exact Mass 247.062683 PSA 106.16000 LogP -0.27 Index of Refraction 1.599 Storage condition Refrigerator Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Naltrexone hydrochloride | 16676-29-2 | 2A-9037193 |
| Doxycycline monohydrate | 17086-28-1 | 2A-9037360 |
| Phenytoin calcium | 17199-74-5 | 2A-9037402 |
| Sodium allopurinol | 17795-21-0 | 2A-9037634 |
| Pomalidomide | 19171-19-8 | 2A-9038038 |
| 11a-Hydroxy-16,17a-epoxyprogesterone | 19427-36-2 | 2A-0202152 |
| Trazodone | 19794-93-5 | 2A-9038215 |
| Memantine | 19982-08-2 | 2A-9038275 |
| tert-Butylpenicillin sodium salt | 20520-33-6 | 2A-9038436 |
| Gliclazide | 21187-98-4 | 2A-9038625 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS