CAS Number22246-18-0
Synonyms3,4-Dihydro-7-hydroxycarbostyril; MFCD06410891; 7-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline; 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone; 7-Hydroxy-3,4-dihydro-quinolin-2-one; 7-Hydroxy-3,4-dihydrochinolin-2(1H)-on; 7-hydroxy-3,4-dihydroquinolin-2(1H)-one; 7-hydroxy-3,4-dihydro-2-quinolinone; 7-Hydroxy-3,4-dihydro carbostyril; 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone; 7-hydroxy-3,4-dihydro-2(1H)quinolinone
Molecular FormulaC9H9NO2
Molecular Weight163.17
Purity97%
Density1.3±0.1 g/cm3
Boiling Point403.7±45.0 °C at 760 mmHg
Melting Point233-237 °C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 22246-18-0 |
| Catalog No. | 2A-9003788 |
| Chinese Name | 3,4-二氢-7-羟基-2(1H)-喹啉酮 |
| Synonyms | 3,4-Dihydro-7-hydroxycarbostyril; MFCD06410891; 7-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline; 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone; 7-Hydroxy-3,4-dihydro-quinolin-2-one; 7-Hydroxy-3,4-dihydrochinolin-2(1H)-on; 7-hydroxy-3,4-dihydroquinolin-2(1H)-one; 7-hydroxy-3,4-dihydro-2-quinolinone; 7-Hydroxy-3,4-dihydro carbostyril; 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone; 7-hydroxy-3,4-dihydro-2(1H)quinolinone |
| Molecular Formula | C9H9NO2 |
| Molecular Weight | 163.17 |
| Purity | 97 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 403.7±45.0 °C at 760 mmHg |
| Melting Point | 233-237 °C |
| Appearance | solid |
| Water Solubility | Soluble in: methanol |
| Application | 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor with an IC50 value of 183 μM and has no effect on MAO-B [1]. |
| HTC | 2933499090 |
| PubChem ID | 24885275 |
| MDL Number | MFCD06410891 |
| SMILES | Oc1ccc2CCC(=O)Nc2c1 |
| InChI | 1S/C9H9NO2/c11-7-3-1-6-2-4-9(12)10-8(6)5-7/h1,3,5,11H,2,4H2,(H,10,12) |
| InChI Key | LKLSFDWYIBUGNT-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Xn |
| Risk Codes | R22-43 |
| Safety Description | S36/37 |
| MSDS | msds/3788_1_22246_18_0.pdf |
| Bioactivity | 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Target IC50: 183 μM (MAO-A)[1] In Vitro 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B[1]. References [1]. Meiring L, et al. Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5498-502. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 403.7±45.0 °C at 760 mmHg Melting Point 233-237 °C Molecular Formula C9H9NO2 Molecular Weight 163.173 Flash Point 198.0±28.7 °C Exact Mass 163.063324 PSA 49.33000 LogP 0.99 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.604 InChIKey LKLSFDWYIBUGNT-UHFFFAOYSA-N SMILES O=C1CCc2ccc(O)cc2N1 |
| Use of | 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B[1]. Properties Name 7-hydroxy-3,4-dihydro-1H-quinolin-2-one Synonym More Synonyms 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Biological Activity Description 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease IC50: 183 μM (MAO-A)[1] In Vitro 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B[1]. References [1]. Meiring L, et al. Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5498-502. Chemical & Physical Properties Molecular Formula C9H9NO2 Exact Mass 163.063324 PSA 49.33000 Index of Refraction 1.604 InChIKey LKLSFDWYIBUGNT-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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