| Chemical & Physical Properties | |
|---|---|
| CAS Number | 10121-91-2 |
| Catalog No. | 2A-9034658 |
| Chinese Name | 丹酰尸胺 |
| Synonyms | Dansylcadaverine; N-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide |
| Molecular Formula | C17H25N3O2S |
| Molecular Weight | 335.46 |
| Purity | 98.00 |
| Density | 1.19g/cm3 |
| Boiling Point | 505.5ºC at 760mmHg |
| Melting Point | 137-140ºC |
| Storage Condition | -20℃, sealed, dry |
| Application | Dansylcadaverine is a fluorescent probe. |
| HTC | 2935009090 |
| PubChem ID | 57648439 |
| SMILES | CN(C)c1cccc2c(S(=O)(=O)NCCCCCN)cccc12 |
| InChI | InChI=1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3 |
| InChI Key | MLEBFEHOJICQQS-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Dansylcadaverine is a fluorescent probe. Related Catalog Signaling Pathways >> Others >> Others Dye Reagents Research Areas >> Others In Vitro Detection of Dansylcadaverine fluorescence after SDS-PAGE shows that the amount of actin-thymosin β4 crosslink is very low in the presence of Dansylcadaverine and transglutaminase, while there are large amounts of Dansylcadaverine-labeled thymosin β4 and actin. The amount of cross-link further decreases in the presence of Dansylcadaverine competing for Lys residues of either G-actin or thymosin β4 (100 μM). In the absence of thymosin β4, Dansylcadaverine-labeled actin polymerized to F-actin as revealed by fluorescence detection after native PAGE[1]. Kinase Assay To determine the time course of transglutamination, thymosin β4 (120 μM) is incubated with Dansylcadaverine (5 mM) in 70 μL buffer consisting of 10 mM Tris-HCl, pH 7.4, 15 mM CaCl2, 3 mM DTT. The reaction is started by addition of 0.1 U transglutaminase. Immediately after addition of the enzyme (t=0) and at indicated times,10 μL are taken from the mixture, diluted in 490 μL 0.1% TFA to stop the reaction and analyzed by HPLC[1]. Cell Assay MCF7 cells (2.4×104) are seeded into 35 mm plates. After 24 h incubation, CuO NPs are added with an increasing concentration in the presence or absence of 3-Methyladenine (3-MA) for different time periods . The cells are then incubated with 50 mM Dansylcadaverine (MDC) at 37°C for 15 min and washed with 1×PBS three times with 5 min interval. Finally, the cells are observed under a fluorescence microscope[2]. References [1]. Huff T, et al. Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescentdansylcadaverine does not abolish interaction with G-actin. FEBS Lett. 1999 Dec 24;464(1-2):14-20. [2]. Laha D, et al. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7. Biochim Biophys Acta. 2014 Jan;1840(1):1-9. Chemical & Physical Properties Density 1.19g/cm3 Boiling Point 505.5ºC at 760mmHg Melting Point 137-140ºC Molecular Formula C17H25N3O2S Molecular Weight 335.46400 Flash Point 259.5ºC Exact Mass 335.16700 PSA 83.81000 LogP 4.48510 Vapour Pressure 9.54E-11mmHg at 25°C Index of Refraction 1.594 InChIKey MLEBFEHOJICQQS-UHFFFAOYSA-N SMILES CN(C)c1cccc2c(S(=O)(=O)NCCCCCN)cccc12 |
| Use of | Dansylcadaverine is a fluorescent probe. Properties Articles58 Name monodansylcadaverine Synonym More Synonyms Dansylcadaverine Biological Activity Description Dansylcadaverine is a fluorescent probe. Related Catalog Signaling Pathways >> Others >> Others Dye Reagents Research Areas >> Others References [1]. Huff T, et al. Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescentdansylcadaverine does not abolish interaction with G-actin. FEBS Lett. 1999 Dec 24;464(1-2):14-20. [2]. Laha D, et al. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7. Biochim Biophys Acta. 2014 Jan;1840(1):1-9. Chemical & Physical Properties Molecular Formula C17H25N3O2S Exact Mass 335.16700 PSA 83.81000 LogP 4.48510 Index of Refraction 1.594 InChIKey MLEBFEHOJICQQS-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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