CAS Number7081-40-5
Synonyms1-Methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine hydrochloride hydrete; Methixene hydrochloride hydrete; Methixene hydrochloride hydrate
Molecular FormulaC20H26ClNOS
Molecular Weight363.94500
Purity98.00%
Boiling Point419.7ºC at 760 mmHg
Melting Point215-217°
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 7081-40-5 |
| Catalog No. | 2A-9033386 |
| Chinese Name | 盐酸麦塞散 |
| Synonyms | 1-Methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine hydrochloride hydrete; Methixene hydrochloride hydrete; Methixene hydrochloride hydrate |
| Molecular Formula | C20H26ClNOS |
| Molecular Weight | 363.94500 |
| Purity | 98.00 |
| Boiling Point | 419.7ºC at 760 mmHg |
| Melting Point | 215-217° |
| Application | Metixene hydrochloride hydrate is an anticholinergic and antiparkinsonian agent that can effectively inhibit the binding of quinine diphenyl glycolate to muscarinic receptors, with IC50 and Kd values |
| HTC | 2934999090 |
| SMILES | S1c2c(cccc2)C(c4c1cccc4)CC3CN(CCC3)C.[Cl-].O.[H+] |
| InChI | 1S/C20H23NS.ClH.H2O/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20;;/h2-5,8-11,15,18H,6-7,12-14H2,1H3;1H;1H2 |
| InChI Key | RAOHHYUBMJLHNC-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/33386_1_7081_40_5.pdf |
| Use of | Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1]. Properties Name methixene hydrochloride Synonym More Synonyms Metixene hydrochloride hydrate Biological Activity Description Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease IC50: 55 nM (mAChR)[1] Ki: 15 nM (mAChR)[1] In Vitro Metixene hydrochloride hydrate is an anticholinergic antiparkinsonian agent, potently inhibits binding of quinuclidinyl benzilate (QNB) to the muscarinic receptor in rat brain cortical tissue, with an IC50 of 55 nM and a Kd of 15 nM[1]. References [1]. Syvälahti EK, et al. Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacol Toxicol. 1988 Feb;62(2):90-4. Chemical & Physical Properties Exact Mass 363.14200 PSA 37.77000 LogP 5.69060 InChIKey RAOHHYUBMJLHNC-UHFFFAOYSA-N Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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