CAS Number6640-22-8
SynonymsPamoic acid disodium salt; embonic acid disodium salt; MFCD00036183; pamoate disodique; disodium 4,4'-methylene-bis(3-hydroxy-2-naphthoate); dipotassium pamoate(2-); sodium embonate; Disodium 4,4'-methylenebis(3-hydroxy-2-naphthoate); Pamoic acid,disodium salt; PAMOIC ACID,Na; Sodium pamoate; disodium 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate; Disodium pamoate; disodium 4-[(3-carboxylato-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate; 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, sodium salt (1:2); Disodium methylenebis(2-hydroxy-3-naphthoate); EINECS 229-653-1
Molecular FormulaC23H14O6Na2
Molecular Weight432.33
Purity98.00%
Boiling Point642.7ºC at 760 mmHg
Melting Point300 °C
Appearancepowder
EINECS229-653-1
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6640-22-8 |
| Catalog No. | 2A-9033061 |
| Chinese Name | 帕莫酸二钠盐一水合物 |
| Synonyms | Pamoic acid disodium salt; embonic acid disodium salt; MFCD00036183; pamoate disodique; disodium 4,4'-methylene-bis(3-hydroxy-2-naphthoate); dipotassium pamoate(2-); sodium embonate; Disodium 4,4'-methylenebis(3-hydroxy-2-naphthoate); Pamoic acid,disodium salt; PAMOIC ACID,Na; Sodium pamoate; disodium 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate; Disodium pamoate; disodium 4-[(3-carboxylato-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate; 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, sodium salt (1:2); Disodium methylenebis(2-hydroxy-3-naphthoate); EINECS 229-653-1 |
| Molecular Formula | C23H14O6Na2 |
| Molecular Weight | 432.33 |
| Purity | 98.00 |
| Boiling Point | 642.7ºC at 760 mmHg |
| Melting Point | 300 °C |
| Appearance | powder |
| Storage Condition | room temperature |
| Application | Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. |
| EINECS | 229-653-1 |
| PubChem ID | 24898580 |
| MDL Number | MFCD00036183 |
| SMILES | [Na].OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(O)=O)c1O |
| InChI | 1S/C23H16O6.Na.H/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;;/h1-10,24-25H,11H2,(H,26,27)(H,28,29);; |
| InChI Key | ZRZSXMUASGHHKP-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352106 |
| MSDS | msds/33061_1_6640_22_8.pdf |
| Bioactivity | Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect[1]. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK Target EC50: 79 nM (GPR35), 65 nM (ERK1/2)[1] References [1]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8. Chemical & Physical Properties Boiling Point 642.7ºC at 760 mmHg Melting Point 300 °C Molecular Formula C23H14Na2O6 Molecular Weight 432.333 Flash Point 356.5ºC Exact Mass 432.058563 PSA 120.72000 LogP 1.72200 InChIKey YGLLICRFEVEWOZ-UHFFFAOYSA-L SMILES O=C(O)c1cc2ccccc2c(Cc2c([O-])c(C(=O)O)cc3ccccc23)c1[O-].[Na+].[Na+] |
| Use of | Properties Name disodium,3-carboxy-1-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]naphthalen-2-olate Synonym More Synonyms Pamoic acid disodium Biological Activity Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK References [1]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8. Chemical & Physical Properties Molecular Formula C23H14Na2O6 Exact Mass 432.058563 PSA 120.72000 LogP 1.72200 InChIKey YGLLICRFEVEWOZ-UHFFFAOYSA-L |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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