CAS Number6147-11-1
Synonyms1,3,6-Trihydroxy-7-methoxy-2,8-di(3-methyl-2-butenyl)xanthone; Mangostin; 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one; alpha-mangostin; EINECS 448-420-7; a-Mangostin; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one; 1,3,6-Trihydroxy-7-méthoxy-2,8-bis(3-méthyl-2-butèn-1-yl)-9H-xanthén-9-one; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one; MFCD00135200
Molecular FormulaC24H26O6
Molecular Weight410.46
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point640.1±55.0 °C at 760 mmHg
Melting Point182ºC
Appearancepowder
EINECS448-420-7
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6147-11-1 |
| Catalog No. | 2A-9032518 |
| Chinese Name | α-倒捻子素 |
| Synonyms | 1,3,6-Trihydroxy-7-methoxy-2,8-di(3-methyl-2-butenyl)xanthone; Mangostin; 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one; alpha-mangostin; EINECS 448-420-7; a-Mangostin; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one; 1,3,6-Trihydroxy-7-méthoxy-2,8-bis(3-méthyl-2-butèn-1-yl)-9H-xanthén-9-one; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one; 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one; MFCD00135200 |
| Molecular Formula | C24H26O6 |
| Molecular Weight | 410.46 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 640.1±55.0 °C at 760 mmHg |
| Melting Point | 182ºC |
| Appearance | powder |
| Water Solubility | Soluble in: methanol |
| Storage Condition | 2-8°C |
| Application | Alpha-mangostin is a dietary xanthone with a wide range of biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anti-cancer effects. It is an inhi |
| EINECS | 448-420-7 |
| HTC | 2932999099 |
| PubChem ID | 329817982 |
| MDL Number | MFCD00135200 |
| SMILES | COc1c(O)cc2Oc3cc(O)c(C\C=C(\C)C)c(O)c3C(=O)c2c1C\C=C(/C)C |
| InChI | 1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3 |
| InChI Key | GNRIZKKCNOBBMO-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352212 |
| MSDS | msds/32518_1_6147_11_1.pdf |
| Use of | Alpha-mangostin is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Properties Articles27 Name α-mangostin Synonym More Synonyms alpha-Mangostin Biological Activity Description Alpha-mangostin is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Others IC50: 2.85 μM (IDH1-R132H)[1] In Vivo Alpha-mangostin reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone[4]. References [1]. Kim HJ, et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5625-31. [2]. Lee HN, et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48. Chemical & Physical Properties Molecular Formula C24H26O6 Exact Mass 410.172943 PSA 100.13000 Index of Refraction 1.624 InChIKey GNRIZKKCNOBBMO-UHFFFAOYSA-N Safety Information Signal Word Danger Hazard Statements H301 Precautionary Statements P301 + P310 Hazard Codes T Risk Phrases 25 Safety Phrases 45 RTECS ZD6122420 HS Code 2932999099 Synthetic Route (4,6-dihydroxy-... 426820-49-7 alpha-Mangostin Literature: Tetrahedron Letters, , vol. 43, # 2 p. 291 - 293 Phloroglucinol alpha-Mangostin Literature: Tetrahedron Letters, , vol. 43, # 2 p. 291 - 293 2-[3-(1,3-benzo... alpha-Mangostin Literature: Tetrahedron Letters, , vol. 43, # 2 p. 291 - 293 Precursor & DownStream Precursor 10 CAS#:426820-49-7 (4,6-dihydroxy-... CAS#:108-73-6 Phloroglucinol CAS#:6195-80-8 2-[3-(1,3-benzo... CAS#:13246-46-3 2,4-bis(phenylm... DownStream 9 CAS#:19275-46-8 5,9-Dihydroxy-8... CAS#:19275-44-6 1-Isomangostin CAS#:26063-96-7 3-Isomangostin ... CAS#:112649-47-5 3,4-dihydro-5,9... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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