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Triprolidine hydrochloride structure, CAS 6138-79-0

Triprolidine hydrochloride

CAS Number6138-79-0

SynonymsMFCD00150574; Triprolidine hydrochloride

Molecular FormulaC19H25ClN2O

Molecular Weight314.85

Purity≥99%

Density

Boiling Point462ºC at 760 mmHg

Melting Point115-120ºC

Flash Point

AppearanceWhite crystalline powder

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Symbol

Signal Word

Cat. No.: 2A-9032507 Purity: ≥99%
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Quality Control of [ 6138-79-0 ] Purity: ≥99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number6138-79-0
Catalog No.2A-9032507
Chinese Name盐酸曲普利啶
SynonymsMFCD00150574; Triprolidine hydrochloride
Molecular FormulaC19H25ClN2O
Molecular Weight314.85
Purity≥99
Boiling Point462ºC at 760 mmHg
Melting Point115-120ºC
AppearanceWhite crystalline powder
Water Solubility≥10 g/100 mL at 20 ºC
Storage Condition2-8°C
ApplicationTriprolidine hydrochloride is an orally active, cell-permeable, first-generation histamine H1 antagonist [1]. Triprolidine hydrochloride is an antihistamine that can be used for allergic rhinitis, ast
PubChem ID24277808
MDL NumberMFCD00039044
SMILESCC(C=C1)=CC=C1/C(C2=NC=CC=C2)=C\CN3CCCC3.Cl
InChI1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
InChI KeyWYUYEJNGHIOFOC-NWBUNABESA-N
NACRES CodeNA.77
UNSPSC12352200
MSDSmsds/32507_1_6138_79_0.pdf
BioactivityTriprolidine hydrochloride monohydrate is an orally active, cell-permeable and first-generation histamine H1 antagonist[1]. Triprolidine hydrochloride monohydrate is an antihistamine and can be used in allergic rhinitis; asthma; and urticaria[2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Target H1 Receptor In Vivo Triprolidine (intraseptal infusion; 0.5 μM in 0.5 μl; 30, 60, and 180 min after tetanus) had no significant effects on the baseline fEPSPs, however, it is followed by a smaller Long-term potentiation (LTP) induced during walking (173% of the baseline at 60 min) compared with saline infusion (208% at 60 min) in rats[2]. Animal Model: Adult male Long-Evans TMN (tuberomammillary nucleus (TMN) neurons) lesion rats[2] Dosage: 0.5 μm in 0.5 μl Administration: Intraseptal infusion; 30, 60, and 180 min after tetanus Result: Attenuated the walking-associated enhancement of LTP. References [1]. Tao Luo, et al. Endogenous Histamine Facilitates Long-Term Potentiation in the Hippocampus During WalkingJ Neurosci. 2010 Jun 9;30(23):7845-52. [2]. Sang-Chul Shin, et al. Controlled Release of Triprolidine Using Ethylene-Vinyl Acetate Membrane and Matrix Systems. Eur J Pharm Biopharm Chemical & Physical Properties Boiling Point 462ºC at 760 mmHg Melting Point 115-120ºC Molecular Formula C19H25ClN2O Molecular Weight 314.85200 Flash Point 233.2ºC Exact Mass 314.15500 PSA 16.13000 LogP 4.65740 InChIKey WYUYEJNGHIOFOC-NWBUNABESA-N SMILES Cc1ccc(C(=CCN2CCCC2)c2ccccn2)cc1.Cl Storage condition 2-8°C Stability Stable, but discolours in light. Incompatible with strong oxidizing agents. Water Solubility ≥10 g/100 mL at 20 ºC
Use ofTriprolidine hydrochloride monohydrate is an orally active, cell-permeable and first-generation histamine H1 antagonist[1]. Triprolidine hydrochloride monohydrate is an antihistamine and can be used in allergic rhinitis; asthma; and urticaria[2]. Properties Articles29 Name triprolidine hydrochloride monohydrate Synonym More Synonyms Triprolidine hydrochloride Biological Activity Description Triprolidine hydrochloride monohydrate is an orally active, cell-permeable and first-generation histamine H1 antagonist[1]. Triprolidine hydrochloride monohydrate is an antihistamine and can be used in allergic rhinitis; asthma; and urticaria[2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H1 Receptor References [1]. Tao Luo, et al. Endogenous Histamine Facilitates Long-Term Potentiation in the Hippocampus During WalkingJ Neurosci. 2010 Jun 9;30(23):7845-52. [2]. Sang-Chul Shin, et al. Controlled Release of Triprolidine Using Ethylene-Vinyl Acetate Membrane and Matrix Systems. Eur J Pharm Biopharm Chemical & Physical Properties Exact Mass 314.15500 PSA 16.13000 LogP 4.65740 InChIKey WYUYEJNGHIOFOC-NWBUNABESA-N Stability Stable, but discolours in light. Incompatible with strong oxidizing agents.
Transport InfoProduct name: trans-tripridine hydrochloride
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