CAS Number5719-85-7
Synonyms1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea; hydroxymethyl-TB; 4-OH-tolbutamide; Methylhydroxytolbutamide; hydroxymethyltolbutamide; Hydroxytolbutamide; 4-Hydroxytolbutamide; 4 hydroxy tolbutamide; N-(Butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide; N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide; 1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea
Molecular FormulaC12H18N2O4S
Molecular Weight286.347
Purity98.00%
Density1.3±0.1 g/cm3
Melting Point100-102ºC
AppearanceWhite to off-white
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5719-85-7 |
| Catalog No. | 2A-9032093 |
| Chinese Name | 4-羟基甲苯磺丁脲 |
| Synonyms | 1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea; hydroxymethyl-TB; 4-OH-tolbutamide; Methylhydroxytolbutamide; hydroxymethyltolbutamide; Hydroxytolbutamide; 4-Hydroxytolbutamide; 4 hydroxy tolbutamide; N-(Butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide; N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide; 1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea |
| Molecular Formula | C12H18N2O4S |
| Molecular Weight | 286.347 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Melting Point | 100-102ºC |
| Appearance | White to off-white |
| Water Solubility | ethanol: 12 mg/mL |
| Storage Condition | 2-8°C |
| Application | 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized in vivo by CYP2C8 and CYP2C9. Tolbutamide is a first-generation potassium channel blocker |
| HTC | 29350090 |
| SMILES | CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1 |
| InChI | InChI=1S/C16H10FN3O3S/c17-11-3-5-12(6-4-11)18-16-19-15(21)14(24-16)9-10-1-7-13(8-2-10)20(22)23/h1-9H,(H,18,19,21)/b14-9+ |
| InChI Key | SJRHYONYKZIRPM-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/32093_2_5719_85_7.pdf |
| Bioactivity | 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Target Potassium channel References [1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71. [2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Melting Point 100-102ºC Molecular Formula C12H18N2O4S Molecular Weight 286.347 Flash Point 2℃ Exact Mass 286.098724 PSA 103.88000 LogP 0.70 Index of Refraction 1.553 InChIKey SJRHYONYKZIRPM-UHFFFAOYSA-N SMILES CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1 Storage condition 2-8°C Water Solubility ethanol: 12 mg/mL |
| Use of | Properties Articles38 Name 4-hydroxytolbutamide Synonym More Synonyms 4 hydroxy tolbutamide Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Potassium channel References [1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71. [2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9. Chemical & Physical Properties Molecular Formula C12H18N2O4S Exact Mass 286.098724 PSA 103.88000 Index of Refraction 1.553 InChIKey SJRHYONYKZIRPM-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available The company is not responsible for any damage caused by any operation or contact with the above products. For more terms of use, see invoice or package The reverse side of the mounting strip. |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| N-Benzyl-N-phenylhydrazine hydrochloride | 5705-15-7 | 2A-9032084 |
| 4-Ethylbiphenyl | 5707-44-8 | 2A-9032085 |
| Guanoxan sulfate | 5714-04-5 | 2A-9032088 |
| Methenamine hippurate | 5714-73-8 | 2A-9032089 |
| Sodium hexamethylene-1,6-bisthiosulfate dihydrate | 5719-73-3 | 2A-9032092 |
| Resorufin methyl ether | 5725-89-3 | 2A-9032100 |
| 7-Ethoxyresorufin | 5725-91-7 | 2A-9032101 |
| 2-Methylcyclohexyl acetate | 5726-19-2 | 2A-9032102 |
| 4-Biphenylacetic acid | 5728-52-9 | 2A-9032105 |
| 4'-Ethyl-4-biphenylamine | 5728-70-1 | 2A-9032106 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS