CAS Number4238-71-5
Synonyms1-BENZYL IMIDAZOLE; MFCD00005296; Imidazole,1-benzyl; 1-benzylimidazole; BENZYLIMIDAZOLE; 1-Benzyl-1H-imidazole; N-benzylimidazole; EINECS 224-200-4; 3-Benzylimidazole
Molecular FormulaC10H10N2
Molecular Weight158.20
Purity99%
Density1.0±0.1 g/cm3
Boiling Point310 °C (lit.)
Melting Point68-70 °C (lit.)
Appearancewhite crystal
EINECS224-200-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4238-71-5 |
| Catalog No. | 2A-9030687 |
| Chinese Name | N-苄基咪唑 |
| Synonyms | 1-BENZYL IMIDAZOLE; MFCD00005296; Imidazole,1-benzyl; 1-benzylimidazole; BENZYLIMIDAZOLE; 1-Benzyl-1H-imidazole; N-benzylimidazole; EINECS 224-200-4; 3-Benzylimidazole |
| Molecular Formula | C10H10N2 |
| Molecular Weight | 158.20 |
| Purity | 99 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 310 °C (lit.) |
| Melting Point | 68-70 °C (lit.) |
| Appearance | white crystal |
| Water Solubility | insoluble |
| Storage Condition | Keep away from light, in a ventilated and dry plac |
| Application | 1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science-related research. |
| EINECS | 224-200-4 |
| HTC | 2933290090 |
| PubChem ID | 24847290 |
| MDL Number | MFCD00005296 |
| SMILES | C(c1ccccc1)n2ccnc2 |
| InChI | 1S/C10H10N2/c1-2-4-10(5-3-1)8-12-7-6-11-9-12/h1-7,9H,8H2 |
| InChI Key | KKKDZZRICRFGSD-UHFFFAOYSA-N |
| Beilstein/REAXYS | 114571 |
| NACRES Code | NA.22 |
| eCl@ss | 39161001 |
| UNSPSC | 12352005 |
| Hazard Symbols | transportation |
| MSDS | msds/30687_1_4238_71_5.pdf |
| Bioactivity | 1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Related Catalog Research Areas >> Others In Vitro Benzylimidazole is a selective thromboxane synthase inhibitor and UDP-glucosyltransferase stimulator. Thromboxane synthase is a cytochrome P450 enzyme. Cytochrome P450 proteins are involved in catalyzing many reactions in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This enzyme plays an important role in several pathophysiological processes, including hemostasis, cardiovascular disease, and stroke. This gene expresses two transcript variants. 1-Benzimidazole selectively inhibits the activity of thromboxane synthase. 1-Benzimidazole reduces TXB2 levels and increases blood flow after cerebral ischemia-reperfusion injury in rats. Gastric administration of 1-benzimidazole (25, 75, and 100 mg/kg/day) induced dose-dependent hepatitis in male Wistar rats. 1-Benzimidazole reduces plasma triglyceride levels by 60-70%. 1-Benzimidazole stimulates three different forms of UDP-glucuronyltransferase. The activity of 1-benzimidazole was significantly increased against 4-methylthrinone, 1-naphthol, morphine, and nopol, a monoterpenoid alcohol. Benzimidazoles increase hepatocyte CYP1A catalytic activity and CYP1A mRNA in a concentration-dependent manner. References [1]. Pettigrew LC, Grotta JC, Rhoades HM, et al. Effect of thromboxane synthase inhibition on eicosanoid levels and blood flow in ischemic rat brain[J]. Stroke, 1989, 20(5): 627-632 [2]. Magdalou J, Totis M, Boiteux-Antoine AF, et al. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxy hydrolases and UDP-glucuronosyltransferases in rat liver[J]. Biochemical pharmacology, 1988, 37(17): 3297-330 Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science, 1998, 5(3): 153-17 [3]. Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science, 1998, 5(3): 153-17 [4]. Navas JM, Chana A, Herradón B, et al. Induction of CYP1A by the N-imidazole derivative, 1-benzylimidazole[J]. Environmental toxicity and chemistry, 2003, 22(4): 830-83 Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 310.0±11.0 °C at 760 mmHg Melting Point 68-70 °C(lit.) Molecular Formula C10H10N2 Molecular Weight 158.20 Flash Point 141.3±19.3 °C Exact Mass 158.084396 PSA 17.82000 LogP 1.46 Vapor Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.580 InChIKey KKKDZZRICRFGSD-UHFFFAOYSA-N SMILES c1ccc(Cn2ccnc2)cc1 Water Solubility insoluble |
| Use of | 1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Properties Articles38 Name 1-Benzylimidazole Synonym More Synonyms 1-benzylimidazole Biological Activity Description 1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Related Catalog Research Areas >> Others References [1]. Pettigrew LC, Grotta JC, Rhoades HM, et al. Effect of thromboxane synthase inhibition on eicosanoid levels and blood flow in ischemic rat brain[J]. Stroke, 1989, 20(5): 627-632 [2]. Magdalou J, Totis M, Boiteux-Antoine AF, et al. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxy hydrolases and UDP-glucuronosyltransferases in rat liver[J]. Biochemical pharmacology, 1988, 37(17): 3297-330 Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science , 1998, 5(3): 153-17 [3]. Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science, 1998, 5(3): 153-17 [4]. Navas JM, Chana A, Herradón B, et al. Induction of CYP1A by the N‐imidazole derivative, 1‐benzylimidazole[J]. Environmental toxicity and chemistry, 2003, 22(4): 830-83 Chemical & Physical Properties Molecular Formula C10H10N2 Exact Mass 158.084396 PSA 17.82000 Index of Refraction 1.580 InChIKey KKKDZZRICRFGSD-UHFFFAOYSA-N Water Solubility insoluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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