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2'-Deoxyinosine structure, CAS 890-38-0

2'-Deoxyinosine

CAS Number890-38-0

SynonymsInosine,2'-deoxy; EINECS 212-964-1; 2'-Deoxyinosine; 9-(2-deoxy-b-D-erythro-pentofuranosyl)-Hypoxanthine; 9-(2-deoxy-β-D-erythro-pentofuranosyl)-Hypoxanthine; 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one; 9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol; Deoxyinosine; (-)-2'-Deoxyinosine; d-Ino; 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE TRISODIUM SALT,DGTP; MFCD00005762

Molecular FormulaC10H12N4O4

Molecular Weight252.23

Purity≥98%

Density1.9±0.1 g/cm3

Boiling Point620.6±65.0 °C at 760 mmHg

Melting Point250 °C

Flash Point

Appearancepowder

EINECS212-964-1

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9003061 Purity: ≥98%
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Quality Control of [ 890-38-0 ] Purity: ≥98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number890-38-0
Catalog No.2A-9003061
Chinese Name2'-脱氧肌苷
SynonymsInosine,2'-deoxy; EINECS 212-964-1; 2'-Deoxyinosine; 9-(2-deoxy-b-D-erythro-pentofuranosyl)-Hypoxanthine; 9-(2-deoxy-β-D-erythro-pentofuranosyl)-Hypoxanthine; 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one; 9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol; Deoxyinosine; (-)-2'-Deoxyinosine; d-Ino; 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE TRISODIUM SALT,DGTP; MFCD00005762
Molecular FormulaC10H12N4O4
Molecular Weight252.23
Purity≥98
Density1.9±0.1 g/cm3
Boiling Point620.6±65.0 °C at 760 mmHg
Melting Point250 °C
Appearancepowder
Storage ConditionSealed storage at -20°C
Application2'-deoxyadenosine can inhibit the growth of human cancer cell lines and has been found to be related to purine nucleoside phosphorylase (PNP) deficiency.
EINECS212-964-1
HTC2934999090
PubChem ID24893935
MDL NumberMFCD00005762
SMILESOC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(=O)NC=Nc23
InChI1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
InChI KeyVGONTNSXDCQUGY-RRKCRQDMSA-N
Beilstein/REAXYS33517
NACRES CodeNA.51
UNSPSC41106305
Hazard SymbolsTransport
MSDSmsds/3061_1_890_38_0.pdf
Bioactivity2'-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency. Related Catalog Natural Products >> Saccharides and Glycosides Research Areas >> Cancer Research Areas >> Metabolic Disease Target Human Endogenous Metabolite In Vitro In the absence of deoxycoformycin, 2'-deoxyadenosine is primarily deaminated to 2'-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2'-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals[1]. Cell Assay Various amounts of cells, ranging from 1,000 to 900,000, suspended in 3 mL of standard medium, are plated in 35-mm dishes and incubated in the absence (control) and in the presence of both 1 μM dCF and 0.1 mM dAdo, as indicated in each experiment. dCf was added to the standard medium 30 min before 2'-deoxyadenosine (dAdo). Furthermore, an incubation is performed in which 0.1 mM 2'-deoxyadenosine alone is added to the standard medium. After 4 days of incubation, the standard medium is withdrawn, then 0.5 mL of 0.025% trypsin containing 0.02% EDTA is added and kept for few minutes at 37°C. The cells are collected, diluted in an appropriate volume of standard medium, and counted[1]. References [1]. Bemi V, et al. Deoxyadenosine metabolism in a human colon-carcinoma cell line (LoVo) in relation to its cytotoxic effect in combination with deoxycoformycin. Int J Cancer. 1998 Mar 2;75(5):713-20. Chemical & Physical Properties Density 1.9±0.1 g/cm3 Boiling Point 620.6±65.0 °C at 760 mmHg Melting Point 250 °C Molecular Formula C10H12N4O4 Molecular Weight 252.227 Flash Point 329.1±34.3 °C Exact Mass 252.085861 PSA 113.26000 LogP -1.43 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.837 InChIKey VGONTNSXDCQUGY-RRKCRQDMSA-N SMILES O=c1[nH]cnc2c1ncn2C1CC(O)C(CO)O1 Storage condition -20°C
Use of2'-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency. Properties Articles41 Name 2ʼ-deoxyinosine Synonym More Synonyms 2'-Deoxyinosine Biological Activity Description 2'-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency. Related Catalog Natural Products >> Saccharides and Glycosides Research Areas >> Cancer Research Areas >> Metabolic Disease Human Endogenous Metabolite In Vitro In the absence of deoxycoformycin, 2'-deoxyadenosine is primarily deaminated to 2'-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2'-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals[1]. References [1]. Bemi V, et al. Deoxyadenosine metabolism in a human colon-carcinoma cell line (LoVo) in relation to its cytotoxic effect in combination with deoxycoformycin. Int J Cancer. 1998 Mar 2;75(5):713-20. Chemical & Physical Properties Molecular Formula C10H12N4O4 Exact Mass 252.085861 PSA 113.26000 LogP -1.43 Index of Refraction 1.837 InChIKey VGONTNSXDCQUGY-RRKCRQDMSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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