CAS Number3621-38-3
SynonymsNeprotine; YATROIZINE HCL; Neprotin; 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium; 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium; NEPROTINE IODIDE; Jateorrhizine; Jatrorrhizine; jatorrhizine; Jateorhizine; Jatrorrhizin; NEPROTINE HCL; 7,8,13,13a-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium; Yatrorizine
Molecular FormulaC20H20O4N1
Molecular Weight338.38
Purity98.00%
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3621-38-3 |
| Catalog No. | 2A-9030005 |
| Chinese Name | 药根碱 |
| Synonyms | Neprotine; YATROIZINE HCL; Neprotin; 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium; 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium; NEPROTINE IODIDE; Jateorrhizine; Jatrorrhizine; jatorrhizine; Jateorhizine; Jatrorrhizin; NEPROTINE HCL; 7,8,13,13a-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium; Yatrorizine |
| Molecular Formula | C20H20O4N1 |
| Molecular Weight | 338.38 |
| Purity | 98.00 |
| Storage Condition | 2-8°C |
| Application | Jatrorrhizine is a potent orally active uptake-2 transporter inhibitor that can be isolated from various traditional Chinese medicinal plants. Jatrorrhizine plays a critical neuroprotective role in H2 |
| HTC | 2933990090 |
| MDL Number | MFCD01310242 |
| SMILES | COc1cc2c(cc1O)CC[n+]1cc3c(OC)c(OC)ccc3cc1-2 |
| InChI | InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1 |
| InChI Key | MXTLAHSTUOXGQF-UHFFFAOYSA-O |
| MSDS | msds/30005_1_3621_38_3.pdf |
| Use of | Jatrorrhizine is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2]. Properties Articles25 Name 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Synonym More Synonyms Jatrorrhizine Biological Activity Description Jatrorrhizine is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2]. Related Catalog Signaling Pathways >> Others >> Others Uptake-2 transporter[1] References [1]. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243. Chemical & Physical Properties Molecular Formula C20H20NO4+ Exact Mass 338.138672 PSA 51.80000 LogP -1.89 InChIKey MXTLAHSTUOXGQF-UHFFFAOYSA-O Safety Information Signal Word Warning Hazard Statements H400 Precautionary Statements P273 Hazard Codes N Risk Phrases 50 Safety Phrases 61 HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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