CAS Number2564-83-2
SynonymsTanan; 2,6,6-Tetramethylpiperidine N-oxide; 2,2,6,6-Tetramethyl piperidine-N-oxyl; (2,2,6,6-Tetramethyl-1-piperidinyl)oxidanyl; 2,2,6,6-tetramethyl-1-piperidinyloxy radical; 2,2,6,6-Tetramethylpiperidoxyl; free radical,2,2,6,6-Tetramethylpiperidine 1-oxyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy; 2,2,6,6-Tetramethylpiperidine 1-Oxyl Free Radical; 2,2,6,6-Tetramethylpiperidinooxy; Tetramethylpiperidinooxy; T6NTJ AO B1 B1 F1 F1 &&Free Radical; Tanane; tetramethylpiperidinenitroxide; EINECS 219-888-8; (2,2,6,6-Tetramethylpiperidin-1-yl)oxidanyl; TEMPO; 2,2,6,6-tetramethylperidinooxy; 2,2,6,6-tetramethyl-1-piperidinyloxy,free radical; MFCD00009599; 2,2,6,6-Tetramethyl-1-piperidinyloxy,free radical,2,2,6,6-Tetramethylpiperidine 1-oxyl
Molecular FormulaC10H21NO?
Molecular Weight156.25
Purity98.00%
Density1 g/cm3
Boiling Point193°C
Melting Point36-38 °C(lit.)
AppearanceOrange crystals or powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2564-83-2 |
| Catalog No. | 2A-9028750 |
| Chinese Name | 2,2,6,6-四甲基哌啶-1-氧自由基 |
| Synonyms | Tanan; 2,6,6-Tetramethylpiperidine N-oxide; 2,2,6,6-Tetramethyl piperidine-N-oxyl; (2,2,6,6-Tetramethyl-1-piperidinyl)oxidanyl; 2,2,6,6-tetramethyl-1-piperidinyloxy radical; 2,2,6,6-Tetramethylpiperidoxyl; free radical,2,2,6,6-Tetramethylpiperidine 1-oxyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy; 2,2,6,6-Tetramethylpiperidine 1-Oxyl Free Radical; 2,2,6,6-Tetramethylpiperidinooxy; Tetramethylpiperidinooxy; T6NTJ AO B1 B1 F1 F1 &&Free Radical; Tanane; tetramethylpiperidinenitroxide; EINECS 219-888-8; (2,2,6,6-Tetramethylpiperidin-1-yl)oxidanyl; TEMPO; 2,2,6,6-tetramethylperidinooxy; 2,2,6,6-tetramethyl-1-piperidinyloxy,free radical; MFCD00009599; 2,2,6,6-Tetramethyl-1-piperidinyloxy,free radical,2,2,6,6-Tetramethylpiperidine 1-oxyl |
| Molecular Formula | C10H21NO? |
| Molecular Weight | 156.25 |
| Purity | 98.00 |
| Density | 1 g/cm3 |
| Boiling Point | 193°C |
| Melting Point | 36-38 °C(lit.) |
| Appearance | Orange crystals or powder |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Sealed in a cool, dry environment at 2-8ºC |
| Packaging | III |
| Application | Tempo is a classic nitric oxide radical and a selective scavenger of mitochondrial ROS that dismutates superoxide in the catalytic cycle. Tempo induces DNA strand breaks and serves as an organocatalys |
| HTC | 29333999 |
| PubChem ID | 24866699 |
| SMILES | CC1(C)CCCC(C)(C)N1[O] |
| InChI | InChI=1S/C9H18NO/c1-8(2)6-5-7-9(3,4)10(8)11/h5-7H2,1-4H3 |
| InChI Key | QYTDEUPAUMOIOP-UHFFFAOYSA-N |
| Hazard Symbols | 8 |
| Bioactivity | Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS References [1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. [2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. [3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22. [4]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5. Chemical & Physical Properties Density 1 g/cm3 Boiling Point 193°C Melting Point 36-38 °C(lit.) Molecular Formula C10H21NO? Molecular Weight 156.245 Flash Point 154 °F Exact Mass 156.138840 PSA 3.24000 LogP 2.31290 InChIKey QYTDEUPAUMOIOP-UHFFFAOYSA-N SMILES CC1(C)CCCC(C)(C)N1[O] Storage condition 2-8°C Stability Stable. Incompatible with strong acids, strong oxidizing agents. Refrigerate. |
| Use of | Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4]. Properties Articles72 Name tempo Synonym More Synonyms 2,2,6,6-Tetramethylpiperidinooxy Biological Activity Description Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS References [1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. [2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. [3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22. Chemical & Physical Properties Molecular Formula C10H21NO? Exact Mass 156.138840 PSA 3.24000 LogP 2.31290 InChIKey QYTDEUPAUMOIOP-UHFFFAOYSA-N SMILES CC1(C)CCCC(C)(C)N1[O] Stability Stable. Incompatible with strong acids, strong oxidizing agents. Refrigerate. |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3263 International Maritime Danger Regulations: 3263 International Air Transport Danger Regulations: 3263 14.2 United Nations shipping name European Land Transport Dangerous Regulations: CORROSIVE SOLID, BASIC, ORGANIC, N.O.S. (2,2,6,6-Tetramethylpiperidinooxy) IMDG Code: CORROSIVE SOLID, BASIC, ORGANIC, N.O.S. (2,2,6,6-Tetramethylpiperidinooxy) International Air Transport Risk Regulations: Corrosive solid, basic, organic, n.o.s. (2,2,6,6-Tetramethylpiperidinooxy) 14.3 Transport hazard categories European Dangerous Regulations for land transport: 8 International Dangerous Regulations for sea transport: 8 International Dangerous Regulations for air transport: 8 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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