CAS Number2216-51-5
Synonyms(-)-(1R,3R,4S)-Menthol; (−)-menthol; (-)-trans-p-Methan-cis-3-ol; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol; L-Menthol; (-)-(1R,2S,5R)-Menthol; (1R)-(-)-Menthol; DL-Menthol; (-)-p-Menthan-3-ol; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (5-Methyl-2-(1-methylethyl)cyclohexanol; MFCD00062979; UNII:YS08XHA860; (−)-Menthol,(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol,5-Methyl-2-(1-methylethyl)cyclohexanol; Menthol; Minclea; (1R,2S,5R)-(−)-Menthol; levo-menthol; uspmenthol; Levomenthol; (-)-MENTHYL ALCOHOL; (R)-(-)-Menthol; (1R,2S,5R)-5-methyl-2-propan-2-yl-cyclohexan-1-ol; [1R-(1a,2b,5a)]-5-Methyl-2-(1-methylethyl)cyclohexanol; (-)-Menthol; (−)-Menthol,(1R,2S,5R)-(−)-Menthol,(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol; L(-)-Menthol; L-MentholuM; EINECS 218-690-9; (1R,2S,5R)-(-)-Menthol
Molecular FormulaC10H20O
Molecular Weight156.27
Purity98.00%
Density0.9±0.1 g/cm3
Boiling Point215.4±8.0 °C at 760 mmHg
Melting Point41-43ºC
Appearancewhite crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2216-51-5 |
| Catalog No. | 2A-9028164 |
| Chinese Name | (-)-薄荷醇 |
| Synonyms | (-)-(1R,3R,4S)-Menthol; (−)-menthol; (-)-trans-p-Methan-cis-3-ol; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol; L-Menthol; (-)-(1R,2S,5R)-Menthol; (1R)-(-)-Menthol; DL-Menthol; (-)-p-Menthan-3-ol; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (5-Methyl-2-(1-methylethyl)cyclohexanol; MFCD00062979; UNII:YS08XHA860; (−)-Menthol,(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol,5-Methyl-2-(1-methylethyl)cyclohexanol; Menthol; Minclea; (1R,2S,5R)-(−)-Menthol; levo-menthol; uspmenthol; Levomenthol; (-)-MENTHYL ALCOHOL; (R)-(-)-Menthol; (1R,2S,5R)-5-methyl-2-propan-2-yl-cyclohexan-1-ol; [1R-(1a,2b,5a)]-5-Methyl-2-(1-methylethyl)cyclohexanol; (-)-Menthol; (−)-Menthol,(1R,2S,5R)-(−)-Menthol,(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol; L(-)-Menthol; L-MentholuM; EINECS 218-690-9; (1R,2S,5R)-(-)-Menthol |
| Molecular Formula | C10H20O |
| Molecular Weight | 156.27 |
| Purity | 98.00 |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 215.4±8.0 °C at 760 mmHg |
| Melting Point | 41-43ºC |
| Appearance | white crystal |
| Water Solubility | insoluble |
| Storage Condition | Keep container sealed, placed in a tight-fitting c |
| Application | (-)-Menthol is a key component of peppermint oil. (-)-Menthol binds to and activates transient receptor potential M8 (TRPM8), a Ca2+-permeable non-selective cation channel, ultimately increasing [Ca2+ |
| HTC | 29061100 |
| PubChem ID | 3690 |
| SMILES | CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O |
| InChI | InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1 |
| InChI Key | InChIKey=NOOLISFMXDJSKH-KXUCPTDWSA-N |
| Hazard Symbols | transportation |
| Bioactivity | (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Target TRPM8[1] In Vitro (-)-Menthol (Menthol ) per se does not exhibit antiproliferative activity, but it is able to enhance 1α,25(OH)2D3-mediated growth inhibition in LNCaP cells. At high (-)-Menthol concentrations above 1.6 mM, the cells begin to detach from the culture dish[1]. (-)-Menthol (0.8 mM) can increase [Ca2+]i via transmembrane influx or store release pathways. Peak increase in [Ca2+]i was 102.3±39 nM (n=3) in (-)-Menthol alone and 124.5±51 nM (n=3) in combination of 1α,25(OH)2D3 with (-)-Menthol, respectively[1]. Combination of 1α,25(OH)2D3 with (-)-Menthol (0.8 mM) cooperatively modulates bcl-2 and p21 expression[1]. References [1]. Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44(2):125-30. Chemical & Physical Properties Density 0.9±0.1 g/cm3 Boiling Point 215.4±8.0 °C at 760 mmHg Melting Point 41-43ºC Molecular Formula C10H20O Molecular Weight 156.265 Flash Point 93.3±0.0 °C Exact Mass 156.151413 PSA 20.23000 LogP 3.20 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.457 Water Solubility insoluble |
| Use of | (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1]. Properties Articles42 Name (-)-menthol Synonym More Synonyms L-Menthol Biological Activity Description (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer References [1]. Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44(2):125-30. Chemical & Physical Properties Molecular Formula C10H20O Exact Mass 156.151413 PSA 20.23000 Index of Refraction 1.457 Water Solubility insoluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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