CAS Number2150-43-8
Synonyms3,4-DIHYDROXY-BENZOIC ACID METHYL ESTER; 3,4-dihydroxy methyl benzoate; MFCD00016437; 3,4-Dihydroxybenzoic Acid Methyl Ester; Protocatechuic acid,methyl ester; 3,4-dihydroxy-6-methoxycarbonylbenzene; Methyl 3,4-dihydroxybenzoate; Protocatechuic Acid Methyl Ester; Benzoic acid, 3,4-dihydroxy-, methyl ester; Methyl Protocatechuate
Molecular FormulaC8H8O4
Molecular Weight168.15
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point351.5±22.0 °C at 760 mmHg
Melting Point134-135°C
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2150-43-8 |
| Catalog No. | 2A-9028061 |
| Chinese Name | 3,4-二羟基苯甲酸甲酯 |
| Synonyms | 3,4-DIHYDROXY-BENZOIC ACID METHYL ESTER; 3,4-dihydroxy methyl benzoate; MFCD00016437; 3,4-Dihydroxybenzoic Acid Methyl Ester; Protocatechuic acid,methyl ester; 3,4-dihydroxy-6-methoxycarbonylbenzene; Methyl 3,4-dihydroxybenzoate; Protocatechuic Acid Methyl Ester; Benzoic acid, 3,4-dihydroxy-, methyl ester; Methyl Protocatechuate |
| Molecular Formula | C8H8O4 |
| Molecular Weight | 168.15 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 351.5±22.0 °C at 760 mmHg |
| Melting Point | 134-135°C |
| Appearance | White to off-white crystalline powder |
| Storage Condition | The storage place must be away from oxidants, keep |
| Application | Methyl protocatechuate (Protocatechuic acid methyl ester) is the primary metabolite of the antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effects [1]. |
| HTC | 2918290000 |
| PubChem ID | 429401 |
| SMILES | COC(=O)c1ccc(O)c(O)c1 |
| InChI | InChI=1S/C8H8O4/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4,9-10H,1H3 |
| InChI Key | CUFLZUDASVUNOE-UHFFFAOYSA-N |
| Bioactivity | Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect[1]. Related Catalog Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cancer Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology In Vitro Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) alleviates the toxic effects of F- via modulating its bioavailability, intracellular calcium level, mitochondrial membrane integrity and redox signaling in A549 cells[1]. In Vivo Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) (25 or 50 mg/kg bw/day) prevents the cellular F- accumulation and oxidative stress. It prevents the inflammatory and associated fibrosis progression by restoring the expression of RAGE and Nrf2[2]. References [1]. Ameeramja J, et al. Protocatechuic acid methyl ester ameliorates fluoride toxicity in A549 cells. Food Chem Toxicol. 2017 Nov;109(Pt 2):941-950. [2]. Ameeramja J, et al. Protocatechuic acid methyl ester modulates fluoride induced pulmonary toxicity in rats. Food Chem Toxicol. 2018 Aug;118:235-244. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 351.5±22.0 °C at 760 mmHg Melting Point 134-135°C Molecular Formula C8H8O4 Molecular Weight 168.147 Flash Point 148.5±15.8 °C Exact Mass 168.042252 PSA 66.76000 LogP 1.69 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.588 InChIKey CUFLZUDASVUNOE-UHFFFAOYSA-N SMILES COC(=O)c1ccc(O)c(O)c1 |
| Use of | Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect[1]. Properties Name Methyl 3,4-dihydroxybenzoate Synonym More Synonyms Protocatechuic acid methyl ester Biological Activity Description Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect[1]. Related Catalog Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cancer Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology References [2]. Ameeramja J, et al. Protocatechuic acid methyl ester modulates fluoride induced pulmonary toxicity in rats. Food Chem Toxicol. 2018 Aug;118:235-244. Chemical & Physical Properties Molecular Formula C8H8O4 Exact Mass 168.042252 PSA 66.76000 Index of Refraction 1.588 InChIKey CUFLZUDASVUNOE-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards Methyl 3,4-dihydroxybenzoate Modification number: 5 Module 14. Shipping information UN number: not specified |
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