CAS Number1949-89-9
Synonyms2-DEOXY-D-LYXOHEXOSE; 2-deoxy-galactose; 2-deoxy-lyxo-hexose; 2-Deoxy-B-D-Lyxo-Hexose; EINECS 217-765-3; Deoxygalactose; 2-Dexoy-D-Lyxohexose; D-2-Desoxygalactose; D-2-deoxygalactose; 2-Deoxy-D-GalaCLose; D-lyxo-Hexose,2-deoxy; 2-Deoxy-D-galactose; MFCD00014649; DEOXY-D-GALACTOSE,2; 2-deoxy-D-talose; (3R,4R,5R)-3,4,5,6-Tetrahydroxyhexanal
Molecular FormulaC6H12O5
Molecular Weight164.16
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point456.7±45.0 °C at 760 mmHg
Melting Point107-110 °C(lit.)
AppearanceWhite crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1949-89-9 |
| Catalog No. | 2A-9027722 |
| Chinese Name | 2-脱氧-D-半乳糖 |
| Synonyms | 2-DEOXY-D-LYXOHEXOSE; 2-deoxy-galactose; 2-deoxy-lyxo-hexose; 2-Deoxy-B-D-Lyxo-Hexose; EINECS 217-765-3; Deoxygalactose; 2-Dexoy-D-Lyxohexose; D-2-Desoxygalactose; D-2-deoxygalactose; 2-Deoxy-D-GalaCLose; D-lyxo-Hexose,2-deoxy; 2-Deoxy-D-galactose; MFCD00014649; DEOXY-D-GALACTOSE,2; 2-deoxy-D-talose; (3R,4R,5R)-3,4,5,6-Tetrahydroxyhexanal |
| Molecular Formula | C6H12O5 |
| Molecular Weight | 164.16 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 456.7±45.0 °C at 760 mmHg |
| Melting Point | 107-110 °C(lit.) |
| Appearance | White crystalline solid |
| Storage Condition | Keep the container sealed and stored in a cool, dr |
| Application | 2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibit tumor growth. 2-Deoxy-D-galactose is a substance that interferes with fucosylation of sugar macromolecules a |
| HTC | 2912491000 |
| PubChem ID | 14717660 |
| SMILES | O=CCC(O)C(O)C(O)CO |
| InChI | InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6-/m1/s1 |
| InChI Key | VRYALKFFQXWPIH-HSUXUTPPSA-N |
| Bioactivity | 2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease In Vitro 2-Deoxy-D-galactose (1 mM/L; 5 h) is rapid phosphorylation during the first 30 min and decreases to approximately 20% of this rate during the subsequent hours in ascites hepatoma cells[4]. In Vivo 2-Deoxy-D-galactose (380 mg/kg; i.p.; for 6 times) strongly decreases contents of UMP, UDPG, and UDP galactose in rat livers[1]. 2-Deoxy-D-galactose (2-8 μM; intracerebroventricularly injection; once) shows PAR impairment 30 min before the acquisition trial a dose of 4 μM and 15 min delay after do-gal administration[3]. Animal Model: Male adult Wistar rats with passive avoidance response (PAR) acquisition trial[3] Dosage: 2, 4 and 8 μM Administration: Intracerebroventricularly injection; 2-8 μM; once Result: Exhibited PAR disruption at a dose of 4 μM. References [1]. Keppler DO, et al. The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis. Eur J Biochem. 1970 Dec;17(2):246-53. [2]. Krug M, et al. The amnesic substance 2-deoxy-D-galactose suppresses the maintenance of hippocampal LTP. Brain Res. 1991 Feb 1;540(1-2):237-42. [3]. Lorenzini CG, et al. 2-Deoxy-D-galactose effects on passive avoidance memorization in the rat. Neurobiol Learn Mem. 1997 Nov;68(3):317-24. [4]. Smith DF, Keppler DO. 2-Deoxy-D-galactose metabolism in ascites hepatoma cells results in phosphate trapping and glycolysis inhibition. Eur J Biochem. 1977 Feb 15;73(1):83-92. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 456.7±45.0 °C at 760 mmHg Melting Point 107-110 °C(lit.) Molecular Formula C6H12O5 Molecular Weight 164.156 Flash Point 244.1±25.2 °C Exact Mass 164.068466 PSA 90.15000 LogP -3.07 Vapour Pressure 0.0±2.5 mmHg at 25°C Index of Refraction 1.534 InChIKey VRYALKFFQXWPIH-HSUXUTPPSA-N SMILES O=CCC(O)C(O)C(O)CO |
| Use of | 2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo[1]. Properties Name 2-deoxy-D-galactose Synonym More Synonyms 2-Deoxy-D-lyxo-hexose Biological Activity Description 2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Keppler DO, et al. The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis. Eur J Biochem. 1970 Dec;17(2):246-53. [2]. Krug M, et al. The amnesic substance 2-deoxy-D-galactose suppresses the maintenance of hippocampal LTP. Brain Res. 1991 Feb 1;540(1-2):237-42. [3]. Lorenzini CG, et al. 2-Deoxy-D-galactose effects on passive avoidance memorization in the rat. Neurobiol Learn Mem. 1997 Nov;68(3):317-24. [4]. Smith DF, Keppler DO. 2-Deoxy-D-galactose metabolism in ascites hepatoma cells results in phosphate trapping and glycolysis inhibition. Eur J Biochem. 1977 Feb 15;73(1):83-92. Chemical & Physical Properties Molecular Formula C6H12O5 Exact Mass 164.068466 PSA 90.15000 LogP -3.07 Index of Refraction 1.534 InChIKey VRYALKFFQXWPIH-HSUXUTPPSA-N SMILES O=CCC(O)C(O)C(O)CO |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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