CAS Number1596-84-5
SynonymsB-Nine; Daminozide; 4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid; Alar; KYLAR; sADH; succinic acid 2,2-dimethylhydrazide; (4E)-4-(Dimethylhydrazono)-4-hydroxybutanoic acid; 4-(2,2-Dimethylhydrazino)-4-oxobutanoic acid; Succinic 2,2-dimethylhydrazide; dyak; butanedioic acid mono(2,2-dimethylhydrazide); EINECS 216-485-9; Dimas; NINE; Dmasa; DMSA; N-dimethylamino succinamic acid; Succinic acid mono(2,2-dimethylhydrazide); MFCD00002787; N-(dimethylamino)succinamic acid; B-995; Butanedioic acid, mono(2,2-dimethylhydrazide)
Molecular FormulaHO2CCH2CH2CONHN(CH3)2
Molecular Weight160.17
Purity99.00%
Density1.2±0.1 g/cm3
Boiling Point329.5±44.0 °C at 760 mmHg
Melting Point162-164 °C(lit.)
Appearancewhite crystal powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1596-84-5 |
| Catalog No. | 2A-9027101 |
| Chinese Name | 丁酰肼 |
| Synonyms | B-Nine; Daminozide; 4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid; Alar; KYLAR; sADH; succinic acid 2,2-dimethylhydrazide; (4E)-4-(Dimethylhydrazono)-4-hydroxybutanoic acid; 4-(2,2-Dimethylhydrazino)-4-oxobutanoic acid; Succinic 2,2-dimethylhydrazide; dyak; butanedioic acid mono(2,2-dimethylhydrazide); EINECS 216-485-9; Dimas; NINE; Dmasa; DMSA; N-dimethylamino succinamic acid; Succinic acid mono(2,2-dimethylhydrazide); MFCD00002787; N-(dimethylamino)succinamic acid; B-995; Butanedioic acid, mono(2,2-dimethylhydrazide) |
| Molecular Formula | HO2CCH2CH2CONHN(CH3)2 |
| Molecular Weight | 160.17 |
| Purity | 99.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 329.5±44.0 °C at 760 mmHg |
| Melting Point | 162-164 °C(lit.) |
| Appearance | white crystal powder |
| Water Solubility | 100 g/L |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Application | Daminozide (DMASA; DIMG; B 995) is a plant growth regulator that can selectively inhibit the KDM2/7 JmjC subfamily. |
| HTC | 2928000031 |
| PubChem ID | 13179 |
| SMILES | CN(C)NC(=O)CCC(=O)O |
| InChI | InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11) |
| InChI Key | NOQGZXFMHARMLW-UHFFFAOYSA-N |
| Hazard Symbols | Category 6.1 Poisons |
| Bioactivity | Daminozide(DMASA; DIMG; B 995), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.IC50 Value: Target: KDM2/7 JmjCInhibition of shoot elongation in dwarf and tall peas by the 1,1-dimethylhydrazide of succinic acid (B-995) was correlated with the inhibition of the oxidation of tryptamine-2-C(14) to indoleacetaldehyde-2-C(14) in homogenates prepared from epicotyls of young plants treated with B-995. The growth-retarding action of B-995 is attributed to the formation of 1,1-dimethylhydrazine in vivo. This hydrazine strongly inhibited tryptamine oxidation by pea epicotyl homogenates[1]. Daminozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily[2].in vitro: Essential oil content increased with increasing levels of gibberellins and decreased when gibberellin biosynthesis was blocked withdaminozide. With increasing levels of gibberellins, 1,8-cineole and camphor contents increased. Daminozide blocked the accumulation of alpha- and beta-thujone.[3].in vivo: Related Catalog Signaling Pathways >> Epigenetics >> Histone Demethylase Research Areas >> Cancer References [1]. Rose NR, Woon EC, Tumber A, Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43. [2]. Schmiderer C, et al. Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis). J Plant Physiol. 2010 Jul 1;167(10):779-86. [3]. Reed DJ, Moore TC, Anderson JD. Plant Growth Retardant B-995: A Possible Mode of Action. Science. 1965 Jun 11;148(3676):1469-71. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 329.5±44.0 °C at 760 mmHg Melting Point 162-164 °C(lit.) Molecular Formula C6H12N2O3 Molecular Weight 160.171 Flash Point 153.1±28.4 °C Exact Mass 160.084793 PSA 69.64000 LogP -0.50 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.497 InChIKey NOQGZXFMHARMLW-UHFFFAOYSA-N SMILES CN(C)NC(=O)CCC(=O)O Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids, wetting agents, oils, copper-containing compounds. Water Solubility 100 g/L |
| Use of | Properties Articles25 Name daminozide Synonym More Synonyms Daminozide Biological Activity Related Catalog Signaling Pathways >> Epigenetics >> Histone Demethylase Research Areas >> Cancer References [2]. Schmiderer C, et al. Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis). J Plant Physiol. 2010 Jul 1;167(10):779-86. [3]. Reed DJ, Moore TC, Anderson JD. Plant Growth Retardant B-995: A Possible Mode of Action. Science. 1965 Jun 11;148(3676):1469-71. Chemical & Physical Properties Molecular Formula C6H12N2O3 Exact Mass 160.084793 PSA 69.64000 LogP -0.50 Index of Refraction 1.497 InChIKey NOQGZXFMHARMLW-UHFFFAOYSA-N SMILES CN(C)NC(=O)CCC(=O)O Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids, wetting agents, oils, copper-containing compounds. |
| Tax Rebate | 9.0% |
| Supervision | S. Import and export pesticide registration certificate |
| Transport Info | Product name: Chemical name |
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