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Polymyxin B sulfate structure, CAS 1405-20-5

Polymyxin B sulfate

CAS Number1405-20-5

SynonymsMASTIMYXIN; MYP SUPPLEMENT; APPLISORB; PolymyxineBsulfate; POLYMIXIN B SULPHATE; PolymyxinBSulfate(sterile,non-sterile); POLYMYXIN B; POLYMYXIN B (PMB); POLYMIXIN B SULFATE; Polymyxin B Sulfate; AEROSPORIN; EINECS 215-774-7; MFCD00270609; Polymyxin B (Sulfate)

Molecular FormulaC55H96N16O13.H2SO4(PolymyxinB2Sulfate)

Molecular Weight1385.61

Purity98.00%

Density

Boiling Point1651ºC at 760 mmHg

Melting Point217-220°C (dec.)

Flash Point

Appearancepowder

EINECS215-774-7

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9026758 Purity: 98.00%
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Quality Control of [ 1405-20-5 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1405-20-5
Catalog No.2A-9026758
Chinese Name硫酸多粘菌素
SynonymsMASTIMYXIN; MYP SUPPLEMENT; APPLISORB; PolymyxineBsulfate; POLYMIXIN B SULPHATE; PolymyxinBSulfate(sterile,non-sterile); POLYMYXIN B; POLYMYXIN B (PMB); POLYMIXIN B SULFATE; Polymyxin B Sulfate; AEROSPORIN; EINECS 215-774-7; MFCD00270609; Polymyxin B (Sulfate)
Molecular FormulaC55H96N16O13.H2SO4(PolymyxinB2Sulfate)
Molecular Weight1385.61
Purity98.00
Boiling Point1651ºC at 760 mmHg
Melting Point217-220°C (dec.)
Appearancepowder
Water SolubilityH2O: 50 mg/mL
Storage ConditionSealed, store at 2 ºC -8 ºC
PackagingIII
ApplicationPolymyxin B Sulfate is a cationic surfactant antibiotic agent, a mixture of polymyxins B1 and B2, which can increase the permeability of cell membranes.
EINECS215-774-7
MDL NumberMFCD00131991
SMILESO=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
InChI1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI KeyHNDFYNOVSOOGDU-UHFFFAOYSA-N
NACRES CodeNA.76
UNSPSC51283106
Hazard Symbols6.1(b)
MSDSmsds/26758_1_1405_20_5.pdf
BioactivityPolymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane.In vitro: RB50 is resistant to killing by polymyxin B at concentrations up to 100 μg/ml. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Others References [1]. Rolin O et al. Enzymatic modification of lipid A by ArnT protects Bordetella bronchiseptica against cationic peptides and is required for transmission. Infect Immun. 2014 Feb;82(2):491-9. [2]. Pye CC et al. Evaluation of biofilm production by Pseudomonas aeruginosa from canine ears and the impact of biofilm on antimicrobial susceptibility in vitro.Vet Dermatol. 2013 Aug;24(4):446-9 Chemical & Physical Properties Boiling Point 1651ºC at 760 mmHg Melting Point 217-220°C (dec.) Molecular Formula C55H96N16O13.H2SO4(PolymyxinB2Sulfate) Molecular Weight 1287.53 (PolymyxinB2Sulfate) Flash Point 952.3ºC PSA 573.64000 LogP 2.54990 Appearance of Characters powder Vapour Pressure 0mmHg at 25°C InChIKey HFMDLUQUEXNBOP-FNGFGNHXSA-N SMILES CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC1=O)C(C)O.O=S(=O)(O)O Storage condition 2-8°C Water Solubility H2O: 50 mg/mL
Use ofPolymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane.In vitro: RB50 is resistant to killing by polymyxin B at concentrations up to 100 μg/ml. Properties Articles53 Name Polymyxin B sulfate Synonym More Synonyms Polymyxin B Sulfate Biological Activity Description Polymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane.In vitro: RB50 is resistant to killing by polymyxin B at concentrations up to 100 μg/ml. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Others References [1]. Rolin O et al. Enzymatic modification of lipid A by ArnT protects Bordetella bronchiseptica against cationic peptides and is required for transmission. Infect Immun. 2014 Feb;82(2):491-9. [2]. Pye CC et al. Evaluation of biofilm production by Pseudomonas aeruginosa from canine ears and the impact of biofilm on antimicrobial susceptibility in vitro.Vet Dermatol. 2013 Aug;24(4):446-9 Chemical & Physical Properties Molecular Formula C55H96N16O13.H2SO4(PolymyxinB2Sulfate) PSA 573.64000 LogP 2.54990 Appearance of Characters powder InChIKey HFMDLUQUEXNBOP-FNGFGNHXSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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