| Chemical & Physical Properties | |
|---|---|
| CAS Number | 837-52-5 |
| Catalog No. | 2A-9025402 |
| Chinese Name | 7-氯-4-(1-哌嗪基)喹啉 |
| Synonyms | 7-chloro-4-piperazin-1-ylquinoline |
| Molecular Formula | C13H14ClN3 |
| Molecular Weight | 247.72 |
| Purity | 98.00 |
| Density | 1.257 g/cm3 |
| Boiling Point | 433.5ºC at 760 mmHg |
| Melting Point | 113-116ºC |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | 7-Chloro-4-(piperazin-1-yl)quinolones are important medicinal chemical scaffolds. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and inhibits serotonin uptake (IC50 of 50 μM). 7-Ch |
| HTC | 2933990090 |
| PubChem ID | 329792044 |
| MDL Number | MFCD01476123 |
| SMILES | Clc1ccc2c(ccnc2c1)N3CCNCC3 |
| InChI | 1S/C13H14ClN3/c14-10-1-2-11-12(9-10)16-4-3-13(11)17-7-5-15-6-8-17/h1-4,9,15H,5-8H2 |
| InChI Key | DNXNPMDUDGUXOB-UHFFFAOYSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| MSDS | msds/25402_1_837_52_5.pdf |
| Bioactivity | 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1]. Related Catalog Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin References [1]. Aida M Abd El-Sattar El-Azzouny, et al. Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives. Drug Dev Res. 2020 Nov;81(7):786-802. Chemical & Physical Properties Density 1.257 g/cm3 Boiling Point 433.5ºC at 760 mmHg Melting Point 113-116ºC Molecular Formula C13H14ClN3 Molecular Weight 247.72300 Flash Point 216ºC Exact Mass 247.08800 PSA 28.16000 LogP 2.69160 Index of Refraction 1.636 InChIKey DNXNPMDUDGUXOB-UHFFFAOYSA-N SMILES Clc1ccc2c(N3CCNCC3)ccnc2c1 Storage condition 2-8°C |
| Use of | 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1]. Properties Name 7-Chloro-4-(piperazin-1-yl)quinoline Synonym More Synonyms 7-Chloro-4-(piperazin-1-yl)quinoline Biological Activity Description 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1]. Related Catalog Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin References [1]. Aida M Abd El-Sattar El-Azzouny, et al. Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives. Drug Dev Res. 2020 Nov;81(7):786-802. Chemical & Physical Properties Exact Mass 247.08800 PSA 28.16000 LogP 2.69160 Index of Refraction 1.636 InChIKey DNXNPMDUDGUXOB-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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